Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2018645..2019283 Replicon chromosome
Accession NZ_CP058853
Organism Shigella flexneri strain STLEFF_38

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag HZT29_RS09765 Protein ID WP_000813794.1
Coordinates 2018645..2018821 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag HZT29_RS09770 Protein ID WP_001270286.1
Coordinates 2018867..2019283 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZT29_RS09745 (2014264) 2014264..2015439 - 1176 WP_001236261.1 BenE family transporter YdcO -
HZT29_RS09750 (2015531) 2015531..2016067 + 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
HZT29_RS09755 (2016140) 2016140..2018101 + 1962 WP_001301045.1 23S rRNA 5-hydroxycytidine C2501 synthase -
HZT29_RS09760 (2018193) 2018193..2018423 - 231 WP_000494244.1 YncJ family protein -
HZT29_RS09765 (2018645) 2018645..2018821 + 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
HZT29_RS09770 (2018867) 2018867..2019283 + 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
HZT29_RS09775 (2019362) 2019362..2020768 + 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
HZT29_RS09780 (2021013) 2021013..2022158 + 1146 WP_000047421.1 ABC transporter substrate-binding protein -
HZT29_RS09785 (2022176) 2022176..2023189 + 1014 WP_239637368.1 ABC transporter ATP-binding protein -
HZT29_RS09790 (2023190) 2023190..2024131 + 942 WP_001251313.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T167741 WP_000813794.1 NZ_CP058853:2018645-2018821 [Shigella flexneri]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T167741 NZ_CP075374:2846217-2846324 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT167741 WP_001270286.1 NZ_CP058853:2018867-2019283 [Shigella flexneri]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT167741 NZ_CP075374:c2846170-2846104 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References