Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 1396350..1397055 Replicon chromosome
Accession NZ_CP058853
Organism Shigella flexneri strain STLEFF_38

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag HZT29_RS06680 Protein ID WP_222683096.1
Coordinates 1396669..1397055 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag HZT29_RS06675 Protein ID WP_001280945.1
Coordinates 1396350..1396679 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZT29_RS06660 (1391507) 1391507..1392418 + 912 WP_001236042.1 glutathione ABC transporter permease GsiD -
HZT29_RS06665 (1392596) 1392596..1394944 + 2349 WP_240764989.1 EAL domain-containing protein -
HZT29_RS06670 (1394952) 1394952..1396280 + 1329 WP_000086877.1 GGDEF domain-containing protein -
HZT29_RS06675 (1396350) 1396350..1396679 - 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
HZT29_RS06680 (1396669) 1396669..1397055 - 387 WP_222683096.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HZT29_RS06685 (1397281) 1397281..1398606 - 1326 WP_000049367.1 30S ribosomal protein S12 methylthiotransferase RimO -
HZT29_RS06690 (1398819) 1398819..1399202 + 384 WP_000497137.1 biofilm formation regulator BssR -
HZT29_RS06695 (1399313) 1399313..1400428 + 1116 Protein_1302 aldose sugar dehydrogenase YliI -
HZT29_RS06700 (1400425) 1400425..1401051 - 627 WP_001295292.1 glutathione S-transferase GstB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14365.51 Da        Isoelectric Point: 9.7108

>T167736 WP_222683096.1 NZ_CP058853:c1397055-1396669 [Shigella flexneri]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKETKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

>T167736 NZ_CP075374:1404983-1405381 [Escherichia coli]
ATGCTGAAATTCATGCTGGATACCAATATCTGTATTTTCACTATTAAGAATAAACCAGTACATGTCAGAGAGCGGTTTAA
CCTGAATTCTGGCCGGATGTGTATAAGTTCTGTAACATTGATGGAGCTTATCTATGGGGCAGAAAAAAGTCAGATGCCAG
AACGCAATTTGGCGGTGATTGAAGGTTTCGTATCTCGTTTGGAAGTGCTTGATTATGATAGTGCTGCTGCGACGCATACT
GGGCAAATCAGGGCCGAGCTTGCCCGGCAGGGAAGGCCTGTTGGACCTTTTGACCAGATGATAGCGGGACATGCTCGCAG
TCGCGGTTTGATTGTGGTTACCAACAATACCCGAGAGTTTGAGCGAGTGGCGGGAATCAGACTAGAAGATTGGAGCTAA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT167736 WP_001280945.1 NZ_CP058853:c1396679-1396350 [Shigella flexneri]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp

>AT167736 NZ_CP075374:1404756-1404983 [Escherichia coli]
ATGGAAACTACTGTATTTTTAAGTAATCGCAGTCAGGCCGTCAGATTACCGAAAGCGGTCGCTCTGCCAGAGGATGTTAA
GAAAGTAGAAATTATTGCGATTGGTCGTACAAGAATCATCACTCCCGCCGGTGAGTCCTGGGACAGTTGGTTTGATGGCG
AAAATGTGAGTGCGGATTTTATGGATATCCGTGATCAACCCGCAATGCAGGAAAGGGAATCATTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References