Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 823088..823886 Replicon chromosome
Accession NZ_CP058853
Organism Shigella flexneri strain STLEFF_38

Toxin (Protein)


Gene name yeeV Uniprot ID A0A166U9J9
Locus tag HZT29_RS03900 Protein ID WP_000854695.1
Coordinates 823509..823886 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A2U2UUE3
Locus tag HZT29_RS03895 Protein ID WP_016243360.1
Coordinates 823088..823462 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZT29_RS03875 (820764) 820764..821582 + 819 WP_001241366.1 DUF932 domain-containing protein -
HZT29_RS03880 (821664) 821664..822143 + 480 WP_000860084.1 antirestriction protein -
HZT29_RS03885 (822159) 822159..822635 + 477 WP_001186773.1 RadC family protein -
HZT29_RS03890 (822704) 822704..822925 + 222 WP_000692307.1 DUF987 domain-containing protein -
HZT29_RS03895 (823088) 823088..823462 + 375 WP_016243360.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HZT29_RS03900 (823509) 823509..823886 + 378 WP_000854695.1 TA system toxin CbtA family protein Toxin
HZT29_RS03905 (823883) 823883..824371 + 489 WP_032083213.1 DUF5983 family protein -
HZT29_RS03910 (824383) 824383..824580 + 198 WP_000839228.1 DUF957 domain-containing protein -
HZT29_RS03915 (824665) 824665..825513 + 849 WP_001280536.1 DUF4942 domain-containing protein -
HZT29_RS03920 (825606) 825606..826925 - 1320 WP_000144689.1 site-specific integrase -
HZT29_RS03925 (827601) 827601..828116 + 516 WP_239637411.1 ATP-binding protein -
HZT29_RS03930 (828145) 828145..828842 + 698 WP_094096600.1 IS1-like element IS1A family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14062.03 Da        Isoelectric Point: 7.7531

>T167734 WP_000854695.1 NZ_CP058853:823509-823886 [Shigella flexneri]
MKTLPDTHVREASCCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITRGKHPGAKQ

Download         Length: 378 bp

>T167734 NZ_CP075374:906870-907277 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13810.66 Da        Isoelectric Point: 7.0266

>AT167734 WP_016243360.1 NZ_CP058853:823088-823462 [Shigella flexneri]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAPATTS

Download         Length: 375 bp

>AT167734 NZ_CP075374:906623-906889 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A166U9J9

Antitoxin

Source ID Structure
AlphaFold DB A0A2U2UUE3

References