Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 376277..376872 Replicon chromosome
Accession NZ_CP058853
Organism Shigella flexneri strain STLEFF_38

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag HZT29_RS01775 Protein ID WP_000239579.1
Coordinates 376522..376872 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag HZT29_RS01770 Protein ID WP_001223208.1
Coordinates 376277..376528 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZT29_RS01760 (371942) 371942..375721 + 3780 WP_000060901.1 autotransporter assembly complex protein TamB -
HZT29_RS01765 (375724) 375724..376065 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
HZT29_RS01770 (376277) 376277..376528 + 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
HZT29_RS01775 (376522) 376522..376872 + 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
HZT29_RS01780 (376952) 376952..377482 - 531 WP_000055072.1 inorganic diphosphatase -
HZT29_RS01785 (377792) 377792..378748 + 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
HZT29_RS01790 (378888) 378888..380390 + 1503 WP_000205784.1 sugar ABC transporter ATP-binding protein -
HZT29_RS01795 (380404) 380404..381426 + 1023 WP_001295197.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T167730 WP_000239579.1 NZ_CP058853:376522-376872 [Shigella flexneri]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T167730 NZ_CP075374:236861-236968 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAACGGAAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT167730 WP_001223208.1 NZ_CP058853:376277-376528 [Shigella flexneri]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT167730 NZ_CP075374:c236812-236749 [Escherichia coli]
GTCTAGATGCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References