Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 3743823..3744658 | Replicon | chromosome |
| Accession | NZ_CP058846 | ||
| Organism | Shigella flexneri strain STLEFF_35 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A7W4PV54 |
| Locus tag | HZT27_RS18400 | Protein ID | WP_000854821.1 |
| Coordinates | 3743823..3744200 (-) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A4Q1HU91 |
| Locus tag | HZT27_RS18405 | Protein ID | WP_053287563.1 |
| Coordinates | 3744290..3744658 (-) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HZT27_RS18370 (3739473) | 3739473..3741314 | + | 1842 | WP_000437375.1 | RNA polymerase sigma factor RpoD | - |
| HZT27_RS18375 (3741393) | 3741393..3741899 | - | 507 | WP_000228937.1 | G/U mismatch-specific DNA glycosylase | - |
| HZT27_RS18385 (3742199) | 3742199..3743044 | - | 846 | WP_049038750.1 | DUF4942 domain-containing protein | - |
| HZT27_RS18390 (3743129) | 3743129..3743326 | - | 198 | WP_063080560.1 | DUF957 domain-containing protein | - |
| HZT27_RS18395 (3743338) | 3743338..3743826 | - | 489 | WP_240767002.1 | DUF5983 family protein | - |
| HZT27_RS18400 (3743823) | 3743823..3744200 | - | 378 | WP_000854821.1 | type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA | Toxin |
| HZT27_RS18405 (3744290) | 3744290..3744658 | - | 369 | WP_053287563.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| HZT27_RS18410 (3744738) | 3744738..3744959 | - | 222 | WP_000692309.1 | DUF987 domain-containing protein | - |
| HZT27_RS18415 (3745028) | 3745028..3745504 | - | 477 | WP_001186747.1 | RadC family protein | - |
| HZT27_RS18420 (3745519) | 3745519..3746004 | - | 486 | WP_000214317.1 | antirestriction protein | - |
| HZT27_RS18425 (3746095) | 3746095..3746913 | - | 819 | WP_053292454.1 | DUF932 domain-containing protein | - |
| HZT27_RS18430 (3747240) | 3747240..3747650 | - | 411 | Protein_3609 | autotransporter domain-containing protein | - |
| HZT27_RS18435 (3747819) | 3747819..3748691 | - | 873 | WP_129442778.1 | GTPase family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 13930.95 Da Isoelectric Point: 8.5163
>T167702 WP_000854821.1 NZ_CP058846:c3744200-3743823 [Shigella flexneri]
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPGAKQ
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPGAKQ
Download Length: 378 bp
>T167702 NZ_CP075345:3124941-3125414 [Enterobacter kobei]
ATGATTTTTTATCGTCTGGTGACAGGGCGCTATGCCAGCGAAGCGTGGAGCGGAAGTGGTGCAAACCAGTATGGCGGGCG
GTGGAATCATAAAGGCCATCCAGCTGTGTATGTGTCCACCTCCATTTCACTGGCCTCACTGGAGATTTTGGTGCACGTTC
GAAAAGATACTGTACTGAATCAGTACCAGCTTTTCAGCATTGATATCCCGGATGACCAGATTGATTACCTGGATAAAGCG
TGGCTCCCCGAGGACTGGCAGGAAAATCCGGCCCCCGTATCAACGATGGATCTGGGAACCGGTTGGTTGCAGGCTAACAG
CGCCCTCGCACTCATCTTACCCTCCTGCATCATTCCTTATGAAAACAATGCCATCCTTAACCCCTTACATCCGTCCTTCC
ACACGGCGCTCAATTCAGTTCAGCAACTGCCCTTTAATTTTGATACCCGCCTGGCTGAAAAAACCGCACCCTGA
ATGATTTTTTATCGTCTGGTGACAGGGCGCTATGCCAGCGAAGCGTGGAGCGGAAGTGGTGCAAACCAGTATGGCGGGCG
GTGGAATCATAAAGGCCATCCAGCTGTGTATGTGTCCACCTCCATTTCACTGGCCTCACTGGAGATTTTGGTGCACGTTC
GAAAAGATACTGTACTGAATCAGTACCAGCTTTTCAGCATTGATATCCCGGATGACCAGATTGATTACCTGGATAAAGCG
TGGCTCCCCGAGGACTGGCAGGAAAATCCGGCCCCCGTATCAACGATGGATCTGGGAACCGGTTGGTTGCAGGCTAACAG
CGCCCTCGCACTCATCTTACCCTCCTGCATCATTCCTTATGAAAACAATGCCATCCTTAACCCCTTACATCCGTCCTTCC
ACACGGCGCTCAATTCAGTTCAGCAACTGCCCTTTAATTTTGATACCCGCCTGGCTGAAAAAACCGCACCCTGA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13663.36 Da Isoelectric Point: 6.4768
>AT167702 WP_053287563.1 NZ_CP058846:c3744658-3744290 [Shigella flexneri]
VSDTFSGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADSYHLDQAFPLLMKQLELMLTSG
ELNSRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK
VSDTFSGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADSYHLDQAFPLLMKQLELMLTSG
ELNSRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK
Download Length: 369 bp
>AT167702 NZ_CP075345:3124501-3124944 [Enterobacter kobei]
ATGAGAACATGGATCCCCGCGCAGAAACCTGCTGATAACGCGCTTTGGCGGTACGCCGGTTTACCTGCAAACAGAGGTAT
GCGGCTGATTGAATTTCTCAATCAGGGATTACCCGTCAGCGTCCTCGACAATATCCATGAGTGGACGGCGATGTCGAAAG
CGGACATTTTGCGCGTCACCGGAATTAATGAACGTAACGTGGCCCGGCGCAAAAGCGCGGGACGGACGCTGACGCCGGAT
GAAAGCGAACGCGTGGCCCGTTTCGTTCGGGTGCTGGATGCTGCTGTCGACTATTTTGGCAGTAAAGAAGAGGCATGGAA
CTGGCTGCAGGCACCGGTGCGCGGGCTAGGGAATGTTGCCCCTGTCGACCTGATCGCGACCGAAACCGGTGCACTGGAAG
TCACCGACTTGATTGGTCGACTCGAACATGGTGTGTTCGCATGA
ATGAGAACATGGATCCCCGCGCAGAAACCTGCTGATAACGCGCTTTGGCGGTACGCCGGTTTACCTGCAAACAGAGGTAT
GCGGCTGATTGAATTTCTCAATCAGGGATTACCCGTCAGCGTCCTCGACAATATCCATGAGTGGACGGCGATGTCGAAAG
CGGACATTTTGCGCGTCACCGGAATTAATGAACGTAACGTGGCCCGGCGCAAAAGCGCGGGACGGACGCTGACGCCGGAT
GAAAGCGAACGCGTGGCCCGTTTCGTTCGGGTGCTGGATGCTGCTGTCGACTATTTTGGCAGTAAAGAAGAGGCATGGAA
CTGGCTGCAGGCACCGGTGCGCGGGCTAGGGAATGTTGCCCCTGTCGACCTGATCGCGACCGAAACCGGTGCACTGGAAG
TCACCGACTTGATTGGTCGACTCGAACATGGTGTGTTCGCATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7W4PV54 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A4Q1HU91 |