Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 9776..10298 Replicon plasmid unnamed3
Accession NZ_CP058842
Organism Shigella flexneri strain STLEFF_34

Toxin (Protein)


Gene name relE Uniprot ID G3CAN5
Locus tag HZT26_RS24405 Protein ID WP_000220560.1
Coordinates 10017..10298 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G3CAG1
Locus tag HZT26_RS24400 Protein ID WP_000121743.1
Coordinates 9776..10027 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZT26_RS24370 (HZT26_24175) 5161..5391 + 231 WP_000051064.1 plasmid partition protein ParG -
HZT26_RS24375 (HZT26_24180) 5407..5700 + 294 WP_015060510.1 hypothetical protein -
HZT26_RS24380 (HZT26_24185) 5702..6670 + 969 WP_031942372.1 IS5-like element IS903B family transposase -
HZT26_RS24385 (HZT26_24190) 6730..7083 - 354 WP_240763296.1 DNA distortion polypeptide 3 -
HZT26_RS24390 (HZT26_24195) 7220..7666 - 447 WP_001074386.1 hypothetical protein -
HZT26_RS24395 (HZT26_24200) 7706..8542 - 837 WP_001050931.1 RepB family plasmid replication initiator protein -
HZT26_RS24400 (HZT26_24205) 9776..10027 + 252 WP_000121743.1 plasmid stabilization protein Antitoxin
HZT26_RS24405 (HZT26_24210) 10017..10298 + 282 WP_000220560.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HZT26_RS24410 (HZT26_24215) 10444..10767 + 324 WP_001181903.1 hypothetical protein -
HZT26_RS24415 (HZT26_24220) 10812..11057 + 246 WP_000356546.1 hypothetical protein -
HZT26_RS24420 (HZT26_24225) 11047..11262 + 216 WP_001180116.1 hypothetical protein -
HZT26_RS24425 (HZT26_24230) 11355..11684 + 330 WP_000866648.1 hypothetical protein -
HZT26_RS24430 (HZT26_24235) 11727..11906 + 180 WP_000439078.1 hypothetical protein -
HZT26_RS24435 (HZT26_24240) 11976..12125 + 150 WP_000003880.1 hypothetical protein -
HZT26_RS24440 (HZT26_24245) 12138..12410 + 273 WP_000160399.1 hypothetical protein -
HZT26_RS24445 (HZT26_24255) 12736..13281 + 546 WP_015060502.1 DNA distortion polypeptide 1 -
HZT26_RS24450 (HZT26_24260) 13284..14450 + 1167 WP_000539530.1 MobP1 family relaxase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - mrkD / mrkF / mrkA / mrkB / mrkC 1..39202 39202


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11005.83 Da        Isoelectric Point: 10.5938

>T167677 WP_000220560.1 NZ_CP058842:10017-10298 [Shigella flexneri]
MTYELAFDRRALKEWQKLGHTIREQFKKKLAERLENPRVPAARLHGHADRYKIKLRASGYRLVYQVIDEKVVLLVIAVGR
RESSEVYQIADLR

Download         Length: 282 bp

>T167677 NZ_CP075325:c2894030-2893779 [Xanthomonas citri pv. citri]
ATGCAACGGCTGCGCGAATTCCTGAAGCCGAAGAGTCCCGATGCCGCGAGGCGGGCCGGTGAAGCGATTAGGCGCGGCGT
CCAGGCTCTCGGTGCCCACCCTCGAATGGGGCGGCTCATAGAAGATCTGCCTGAACAGTATCGGGAGTGGCTTATCGATT
TTGGGGATAGTGGCTATGTGGCTCGGTACCGCCACGCTGGCGATACCGTCACGATTTTGGCCGTGCGACACCAGAAGGAA
GCGGGGTACTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9194.43 Da        Isoelectric Point: 4.1683

>AT167677 WP_000121743.1 NZ_CP058842:9776-10027 [Shigella flexneri]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKNPEIVKVNL
DDL

Download         Length: 252 bp

>AT167677 NZ_CP075325:c2894335-2894057 [Xanthomonas citri pv. citri]
ATGGTTACGGCAACTTCCATCAAGCTTGATGATGAATTGAAAGGGCGGGTTCAGCACTTGGCCGAGGCGCGCCGGCGTAC
CCCGCATTGGATCATGCGCGAAGCCATTGAGCAGTACGTCGAGCGCGAGGAAAAGCGTGAGGCGTTGAACCGGGACACGC
TCAAGGCATGGGATGAATTTCAGGCGACGGGCCTGCACGTGACCGCTGAGGAAGTGGACAAGTGGCTCGCGAGCTGGGGA
ACAGACGACGAACTGCCTCCGCCAGAATGCCACAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G3CAN5

Antitoxin

Source ID Structure
AlphaFold DB A0A3S5I301

References