Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | ccdAB/CcdA(antitoxin) |
Location | 34496..35021 | Replicon | plasmid unnamed1 |
Accession | NZ_CP058840 | ||
Organism | Shigella flexneri strain STLEFF_34 |
Toxin (Protein)
Gene name | ccdB | Uniprot ID | S1PFV8 |
Locus tag | HZT26_RS23500 | Protein ID | WP_001159871.1 |
Coordinates | 34716..35021 (+) | Length | 102 a.a. |
Antitoxin (Protein)
Gene name | ccdA | Uniprot ID | S1PPD8 |
Locus tag | HZT26_RS23495 | Protein ID | WP_000813634.1 |
Coordinates | 34496..34714 (+) | Length | 73 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
HZT26_RS23475 (29658) | 29658..30416 | + | 759 | WP_000494510.1 | hypothetical protein | - |
HZT26_RS23480 (30707) | 30707..32230 | + | 1524 | WP_000921251.1 | hypothetical protein | - |
HZT26_RS23485 (32265) | 32265..33389 | + | 1125 | WP_000386705.1 | DUF4238 domain-containing protein | - |
HZT26_RS23490 (33389) | 33389..33679 | + | 291 | WP_000648897.1 | hypothetical protein | - |
HZT26_RS23495 (34496) | 34496..34714 | + | 219 | WP_000813634.1 | type II toxin-antitoxin system antitoxin CcdA | Antitoxin |
HZT26_RS23500 (34716) | 34716..35021 | + | 306 | WP_001159871.1 | type II toxin-antitoxin system toxin CcdB | Toxin |
HZT26_RS23505 (35022) | 35022..35831 | + | 810 | WP_000016963.1 | site-specific integrase | - |
HZT26_RS23510 (36003) | 36003..36356 | + | 354 | WP_000864813.1 | colicin M immunity protein | - |
HZT26_RS23515 (36406) | 36406..36975 | - | 570 | Protein_42 | lipid II-degrading bacteriocin colicin M | - |
HZT26_RS23520 (37032) | 37032..37729 | + | 698 | WP_240763292.1 | IS1 family transposase | - |
HZT26_RS23525 (37887) | 37887..38759 | - | 873 | WP_000794337.1 | hypothetical protein | - |
HZT26_RS23530 (38990) | 38990..39687 | + | 698 | WP_223200906.1 | IS1-like element IS1A family transposase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Conjugative plasmid | cmlA1 / qacE / blaCTX-M-14 / erm(B) / mph(A) | - | 1..98962 | 98962 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 102 a.a. Molecular weight: 11692.49 Da Isoelectric Point: 6.4674
>T167674 WP_001159871.1 NZ_CP058840:34716-35021 [Shigella flexneri]
MQFKVYTYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRELYPVVHVGDESWRMMTTDMASVPVSVIGEEV
ADLSHRENDIKNAINLMFWGI
MQFKVYTYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRELYPVVHVGDESWRMMTTDMASVPVSVIGEEV
ADLSHRENDIKNAINLMFWGI
Download Length: 306 bp
>T167674 NZ_CP075325:c2020391-2020050 [Xanthomonas citri pv. citri]
ATGACCAAGACCACCACTACACCGTTCGACCCAGCCGAATACCTCGACGATGACGAGGCAATGGCGACCTACCTCTCCGA
AGCACTCGATTCTGGAGATACCGACCATTTCCAAGACGCTCTGCAGGTCGTGGCGCGCGCACGCGGCATGGCGCAGATTG
CTGAGGCGGCGGGGCTTGGCCGGGAGAGCCTTTACAAGGCGCTCAAGCCTGGTGCGAATCCACGCTTCGACACCATCCAG
CGCGTACTGACTGCGCTGGGCGTCCGTCTGAGCATCGGCCCAGCCGAAACCGTCGAAGCAACTGAAACCGCCAAGGCTGC
CTATACCGTCAGGGCGGCATAA
ATGACCAAGACCACCACTACACCGTTCGACCCAGCCGAATACCTCGACGATGACGAGGCAATGGCGACCTACCTCTCCGA
AGCACTCGATTCTGGAGATACCGACCATTTCCAAGACGCTCTGCAGGTCGTGGCGCGCGCACGCGGCATGGCGCAGATTG
CTGAGGCGGCGGGGCTTGGCCGGGAGAGCCTTTACAAGGCGCTCAAGCCTGGTGCGAATCCACGCTTCGACACCATCCAG
CGCGTACTGACTGCGCTGGGCGTCCGTCTGAGCATCGGCCCAGCCGAAACCGTCGAAGCAACTGAAACCGCCAAGGCTGC
CTATACCGTCAGGGCGGCATAA
Antitoxin
Download Length: 73 a.a. Molecular weight: 8372.34 Da Isoelectric Point: 4.7405
>AT167674 WP_000813634.1 NZ_CP058840:34496-34714 [Shigella flexneri]
MKQRITVTVDSDSYQLLKAYDVNISGLVSTTMQNEARRLRAERWKAENQEGMAEVARFIEMNGSFADENRDW
MKQRITVTVDSDSYQLLKAYDVNISGLVSTTMQNEARRLRAERWKAENQEGMAEVARFIEMNGSFADENRDW
Download Length: 219 bp
>AT167674 NZ_CP075325:c2020714-2020424 [Xanthomonas citri pv. citri]
ATGACGACGATCACCGCAACCGAAGAATTCACCACCTGGCTGCGCAAGCTGCGTGACACCAAGGCCAAGGCCGTGATCAT
TGAACGTGTGCAGCGCGTCGCCCGTGGCCTGCTCGGCGATGTTGAGCCGGTGGGCGGCCCGGTTAGCGAGCTGCGCATCC
ACTACGGACCCGGCTACCGGGTCTACTTCACCCGGCGCGGTGAGGAGGTCGTCATCCTCCTCTGCGGCGGTGACAAGACC
ACCCAGACCAAGGACATCAAGAAAGCGCAAGCCCTCGCCGCCGGCCTCTGA
ATGACGACGATCACCGCAACCGAAGAATTCACCACCTGGCTGCGCAAGCTGCGTGACACCAAGGCCAAGGCCGTGATCAT
TGAACGTGTGCAGCGCGTCGCCCGTGGCCTGCTCGGCGATGTTGAGCCGGTGGGCGGCCCGGTTAGCGAGCTGCGCATCC
ACTACGGACCCGGCTACCGGGTCTACTTCACCCGGCGCGGTGAGGAGGTCGTCATCCTCCTCTGCGGCGGTGACAAGACC
ACCCAGACCAAGGACATCAAGAAAGCGCAAGCCCTCGCCGCCGGCCTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A829CCE8 |
Antitoxin
Source | ID | Structure |
---|---|---|
PDB | 3TCJ | |
PDB | 2H3A | |
PDB | 2ADN | |
PDB | 2ADL | |
PDB | 3HPW | |
PDB | 2H3C | |
PDB | 3G7Z | |
AlphaFold DB | A0A829CQY2 |