Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4279509..4280127 Replicon chromosome
Accession NZ_CP058839
Organism Shigella flexneri strain STLEFF_34

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag HZT26_RS20825 Protein ID WP_001291435.1
Coordinates 4279509..4279727 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag HZT26_RS20830 Protein ID WP_000344800.1
Coordinates 4279753..4280127 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZT26_RS20790 (4274798) 4274798..4275370 + 573 WP_000779831.1 YbaY family lipoprotein -
HZT26_RS20795 (4275401) 4275401..4275712 - 312 WP_000409911.1 MGMT family protein -
HZT26_RS20805 (4276091) 4276091..4276444 + 354 WP_000878140.1 DUF1428 domain-containing protein -
HZT26_RS20810 (4276486) 4276486..4278036 - 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
HZT26_RS20815 (4278200) 4278200..4278670 - 471 WP_000136192.1 YlaC family protein -
HZT26_RS20820 (4278786) 4278786..4279337 - 552 WP_000102564.1 maltose O-acetyltransferase -
HZT26_RS20825 (4279509) 4279509..4279727 - 219 WP_001291435.1 HHA domain-containing protein Toxin
HZT26_RS20830 (4279753) 4279753..4280127 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
HZT26_RS20835 (4280673) 4280673..4283822 - 3150 WP_001132469.1 efflux RND transporter permease AcrB -
HZT26_RS20840 (4283845) 4283845..4285038 - 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T167673 WP_001291435.1 NZ_CP058839:c4279727-4279509 [Shigella flexneri]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T167673 NZ_CP075325:99706-100005 [Xanthomonas citri pv. citri]
ATGGCTGAAATAATCTGGTCGGTGCCGGCATTGGCTGATCTGGACGCAATTGCCGACTACATCGCAATCGATAACGCACC
CGCTGCAGCGGCGCTGGTGAAACGGGTGTTCGGGCACGTTGAGCAATTGATCGAACACCCGGACAGCGGAAGCCGACCAC
AGGAACTCAAGCGCTCGCGCTATCGCCAGATTGTCGAACCACCTTGCCGCGTGTTCTACCGCGTGGATGGGCAGCGCATC
GTGGTGGTGCACGTCATGCGGTCGGAGCGCGCGCTTCGCGGGAACCGTCTTTCACGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT167673 WP_000344800.1 NZ_CP058839:c4280127-4279753 [Shigella flexneri]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT167673 NZ_CP075325:99461-99718 [Xanthomonas citri pv. citri]
ATGCGCACCGAACTTGTCACCACGCTCAAGCGTCAGGCGACCGAACTCCTTGCAGCTGCAGAGCGCGACAAGGAGCCAAT
CCTGATCACACAGCACGGTTTACCCAGTGCCTATCTGGTGGATGTTGCCAGCTATGAGCGCATGCAGCAGCGCATTGCGC
TCCTCGAAGGAATCGCCCGTGGAGAAATGGCAGTCGCGGAAGGCCGTACGCTGAGCCATGAACAGGCACGGCACCGCATG
GCGCGATGGCTGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References