Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1916293..1917127 Replicon chromosome
Accession NZ_CP058839
Organism Shigella flexneri strain STLEFF_34

Toxin (Protein)


Gene name yeeV Uniprot ID A0A2I6F3V8
Locus tag HZT26_RS09380 Protein ID WP_054627366.1
Coordinates 1916750..1917127 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A4Q1HU91
Locus tag HZT26_RS09375 Protein ID WP_053287563.1
Coordinates 1916293..1916661 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZT26_RS09355 (1914038) 1914038..1914856 + 819 WP_096200128.1 DUF932 domain-containing protein -
HZT26_RS09360 (1914947) 1914947..1915432 + 486 WP_000214317.1 antirestriction protein -
HZT26_RS09365 (1915447) 1915447..1915923 + 477 WP_001186747.1 RadC family protein -
HZT26_RS09370 (1915992) 1915992..1916213 + 222 WP_000692312.1 DUF987 domain-containing protein -
HZT26_RS09375 (1916293) 1916293..1916661 + 369 WP_053287563.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HZT26_RS09380 (1916750) 1916750..1917127 + 378 WP_054627366.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
HZT26_RS09385 (1917124) 1917124..1917273 + 150 Protein_1847 DUF5983 family protein -
HZT26_RS09390 (1917349) 1917349..1917546 + 198 WP_023563519.1 DUF957 domain-containing protein -
HZT26_RS09395 (1917631) 1917631..1918476 + 846 WP_063101552.1 DUF4942 domain-containing protein -
HZT26_RS09405 (1919210) 1919210..1921462 + 2253 Protein_1850 alpha-amylase family glycosyl hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13928.97 Da        Isoelectric Point: 8.5163

>T167663 WP_054627366.1 NZ_CP058839:1916750-1917127 [Shigella flexneri]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T167663 NZ_CP075316:c4937002-4936718 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13663.36 Da        Isoelectric Point: 6.4768

>AT167663 WP_053287563.1 NZ_CP058839:1916293-1916661 [Shigella flexneri]
VSDTFSGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADSYHLDQAFPLLMKQLELMLTSG
ELNSRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp

>AT167663 NZ_CP075316:c4937234-4936992 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I6F3V8

Antitoxin

Source ID Structure
AlphaFold DB A0A4Q1HU91

References