Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 716339..716865 | Replicon | chromosome |
| Accession | NZ_CP058839 | ||
| Organism | Shigella flexneri strain STLEFF_34 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | HZT26_RS03595 | Protein ID | WP_000323025.1 |
| Coordinates | 716339..716626 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | HZT26_RS03600 | Protein ID | WP_000534858.1 |
| Coordinates | 716626..716865 (-) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HZT26_RS03545 (711363) | 711363..711578 | - | 216 | WP_000839590.1 | phage lysis protein EssD | - |
| HZT26_RS03550 (711798) | 711798..711968 | + | 171 | WP_211180497.1 | putative zinc-binding protein YnfU | - |
| HZT26_RS03555 (712332) | 712332..712547 | - | 216 | WP_000066484.1 | cold shock-like protein CspB | - |
| HZT26_RS03560 (712848) | 712848..713060 | + | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| HZT26_RS03565 (713115) | 713115..713204 | + | 90 | WP_120795389.1 | hypothetical protein | - |
| HZT26_RS03570 (713482) | 713482..714234 | - | 753 | WP_001047135.1 | antitermination protein | - |
| HZT26_RS03575 (714248) | 714248..715297 | - | 1050 | WP_001265199.1 | DUF968 domain-containing protein | - |
| HZT26_RS03580 (715299) | 715299..715577 | - | 279 | WP_012304870.1 | hypothetical protein | - |
| HZT26_RS03585 (715644) | 715644..715895 | - | 252 | WP_000980994.1 | protein Rem | - |
| HZT26_RS03590 (716112) | 716112..716267 | - | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| HZT26_RS03595 (716339) | 716339..716626 | - | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| HZT26_RS03600 (716626) | 716626..716865 | - | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| HZT26_RS03605 (716890) | 716890..717195 | + | 306 | WP_001326990.1 | protein YdfV | - |
| HZT26_RS03610 (717398) | 717398..717730 | + | 333 | WP_001301033.1 | FlxA-like family protein | - |
| HZT26_RS03615 (718167) | 718167..719480 | - | 1314 | WP_000589005.1 | ISNCY family transposase | - |
| HZT26_RS03620 (720249) | 720249..720536 | - | 288 | Protein_716 | hypothetical protein | - |
| HZT26_RS03625 (720779) | 720779..720901 | + | 123 | Protein_717 | transposase | - |
| HZT26_RS03630 (720907) | 720907..721137 | + | 231 | Protein_718 | IS66 family insertion sequence element accessory protein TnpB | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 701151..728857 | 27706 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T167652 WP_000323025.1 NZ_CP058839:c716626-716339 [Shigella flexneri]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T167652 NZ_CP075316:346070-346438 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT167652 WP_000534858.1 NZ_CP058839:c716865-716626 [Shigella flexneri]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT167652 NZ_CP075316:345852-346073 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|