Detailed information of TA system TA167650

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/UPF0150(antitoxin)
• Location: 578644..579282
• Replicon: chromosome
• Accession: NZ_CP058839
• Organism: Shigella flexneri strain STLEFF_34

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A0A6TXU8
• Locus tag: HZT26_RS02905
• Protein ID: WP_001447010.1
• Coordinates: 578644..578820 (+)
• Length: 59 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: HZT26_RS02910
• Protein ID: WP_001270286.1
• Coordinates: 578866..579282 (+)
• Length: 139 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HZT26_RS02885 (574263)	574263..575438	-	1176	WP_001236265.1	BenE family transporter YdcO	-
HZT26_RS02890 (575530)	575530..576066	+	537	WP_000429155.1	DNA-binding transcriptional regulator SutR	-
HZT26_RS02895 (576139)	576139..578100	+	1962	WP_001303492.1	23S rRNA 5-hydroxycytidine C2501 synthase	-
HZT26_RS02900 (578192)	578192..578422	-	231	WP_000494244.1	YncJ family protein	-
HZT26_RS02905 (578644)	578644..578820	+	177	WP_001447010.1	type II toxin-antitoxin system mRNA interferase toxin HicA	Toxin
HZT26_RS02910 (578866)	578866..579282	+	417	WP_001270286.1	type II toxin-antitoxin system antitoxin HicB	Antitoxin
HZT26_RS02915 (579361)	579361..580767	+	1407	WP_000760626.1	PLP-dependent aminotransferase family protein	-
HZT26_RS02920 (581012)	581012..582157	+	1146	WP_000047424.1	ABC transporter substrate-binding protein	-
HZT26_RS02925 (582175)	582175..583188	+	1014	WP_000220396.1	ABC transporter ATP-binding protein	-
HZT26_RS02930 (583189)	583189..584130	+	942	WP_001251304.1	ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (91-134)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6779.86 Da
• Isoelectric Point: 11.2298

>T167650 WP_001447010.1 NZ_CP058839:578644-578820 [Shigella flexneri]
VKQSEFRRWLESQGVDVANSSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Nucleotide

• Length: 177 bp

>T167650 NZ_CP075287:c66229-65813 [Klebsiella pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACCAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGTGATCGCATTGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCGTCCTGCCCTGGGACCGCGCC
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTAGCCGGGACGCCGATCGGCCCGAATGACACGGCCATTGC
CGGGCACGCCATCGCGGCGGGCGCCATCCTGGTGACGAACAATGTGAGAGAGTTTGCGCGGGTCCCGGGCCTGGTGCTGG
AAGACTGGGTGAAATAA

Antitoxin

Protein

• Length: 139 a.a.
• Molecular weight: 15246.63 Da
• Isoelectric Point: 4.7386

>AT167650 WP_001270286.1 NZ_CP058839:578866-579282 [Shigella flexneri]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Nucleotide

• Length: 417 bp

>AT167650 NZ_CP075287:c66456-66226 [Klebsiella pneumoniae]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGATGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGATCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA

Structures

Toxin

• AlphaFold DB: A0A0A6TXU8