Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/RelE-RHH |
| Location | 9170..9717 | Replicon | plasmid unnamed1 |
| Accession | NZ_CP058832 | ||
| Organism | Shigella flexneri strain STLE4 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | - |
| Locus tag | HZT21_RS22670 | Protein ID | WP_244578848.1 |
| Coordinates | 9170..9448 (-) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | A0A829FT18 |
| Locus tag | HZT21_RS22675 | Protein ID | WP_000079938.1 |
| Coordinates | 9448..9717 (-) | Length | 90 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HZT21_RS22630 | 4303..4371 | + | 69 | WP_211180522.1 | protein YkiE | - |
| HZT21_RS22635 (HZT21_22430) | 4458..5155 | + | 698 | WP_232585763.1 | IS1 family transposase | - |
| HZT21_RS22640 (HZT21_22435) | 5531..6307 | + | 777 | WP_022631027.1 | MBL fold metallo-hydrolase | - |
| HZT21_RS22645 (HZT21_22440) | 6323..7312 | + | 990 | WP_001541953.1 | helix-turn-helix domain-containing protein | - |
| HZT21_RS22650 (HZT21_22445) | 7321..7746 | + | 426 | WP_063072980.1 | ester cyclase | - |
| HZT21_RS22655 (HZT21_22450) | 7941..8045 | + | 105 | Protein_10 | IS3 family transposase | - |
| HZT21_RS22660 (HZT21_22455) | 8349..8642 | + | 294 | WP_223429961.1 | biofilm development regulator YmgB/AriR family protein | - |
| HZT21_RS22665 | 8767..8903 | - | 137 | Protein_12 | IS5/IS1182 family transposase | - |
| HZT21_RS23265 (HZT21_22460) | 8980..9114 | - | 135 | WP_257187774.1 | hypothetical protein | - |
| HZT21_RS22670 (HZT21_22465) | 9170..9448 | - | 279 | WP_244578848.1 | type II toxin-antitoxin system toxin YacB | Toxin |
| HZT21_RS22675 (HZT21_22470) | 9448..9717 | - | 270 | WP_000079938.1 | type II toxin-antitoxin system antitoxin YacA | Antitoxin |
| HZT21_RS22680 (HZT21_22475) | 9790..9930 | - | 141 | WP_160784086.1 | hypothetical protein | - |
| HZT21_RS22685 (HZT21_22480) | 10190..10471 | + | 282 | WP_224732584.1 | Tn3 family transposase | - |
| HZT21_RS22690 (HZT21_22485) | 10670..11674 | - | 1005 | WP_000427623.1 | IS110-like element IS4321 family transposase | - |
| HZT21_RS22695 (HZT21_22490) | 12092..13528 | - | 1437 | WP_000105383.1 | glutathione synthase | - |
| HZT21_RS22700 (HZT21_22495) | 13795..14499 | + | 705 | WP_001067858.1 | IS6-like element IS26 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | aadA2 / dfrA12 / aac(3)-IId / oqxA / oqxB / tet(A) / aph(6)-Id / aph(3'')-Ib / sul2 / blaTEM-1B / floR | - | 1..86483 | 86483 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10729.39 Da Isoelectric Point: 8.4615
>T167622 WP_244578848.1 NZ_CP058832:c9448-9170 [Shigella flexneri]
MEIFWTMLASQDRKRIREYIAEQNLMVAIELDERIGYSASSLAGQPYKGRNGRVEGARELVIHPHFVLVYEVDSPWGKVY
ILRVLHTAQKWP
MEIFWTMLASQDRKRIREYIAEQNLMVAIELDERIGYSASSLAGQPYKGRNGRVEGARELVIHPHFVLVYEVDSPWGKVY
ILRVLHTAQKWP
Download Length: 279 bp
>T167622 NZ_CP075192:3569958-3570263 [Ferribacterium limneticum]
ATGATTGAGATTCGCAAAACGGACGTCTTCGCTCAATGGCTTGATAGCCTGCGCGACATTCAGGCCCGGGCTCGCATTCA
GGTTCGGATCGAACGACTGGCCGCTGGCAATGCCGGTGATGCCGAGCCTGTCGGAGAAGGCGTGTCGGAGTTGCGAATCA
ACCATGGCCCCGGCTACCGGGTGTATTTCAAGAAGCGAGGGCAAGAGCTGATCATTCTGTTGGCCGGGGGAGACAAGAGC
ACCCAGGCCAAAGACATCAAAACAGCCCTGCGCCTCGCTCGTGATCTTTCGGAGCAAGCACCATGA
ATGATTGAGATTCGCAAAACGGACGTCTTCGCTCAATGGCTTGATAGCCTGCGCGACATTCAGGCCCGGGCTCGCATTCA
GGTTCGGATCGAACGACTGGCCGCTGGCAATGCCGGTGATGCCGAGCCTGTCGGAGAAGGCGTGTCGGAGTTGCGAATCA
ACCATGGCCCCGGCTACCGGGTGTATTTCAAGAAGCGAGGGCAAGAGCTGATCATTCTGTTGGCCGGGGGAGACAAGAGC
ACCCAGGCCAAAGACATCAAAACAGCCCTGCGCCTCGCTCGTGATCTTTCGGAGCAAGCACCATGA
Antitoxin
Download Length: 90 a.a. Molecular weight: 10251.64 Da Isoelectric Point: 10.1734
>AT167622 WP_000079938.1 NZ_CP058832:c9717-9448 [Shigella flexneri]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVAAGRQQLKRGDVLPHDMVESSAAAWRD
EMSRKVADK
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVAAGRQQLKRGDVLPHDMVESSAAAWRD
EMSRKVADK
Download Length: 270 bp
>AT167622 NZ_CP075192:3570260-3570559 [Ferribacterium limneticum]
ATGACCAAAACCGCTACCACCCGCTACGACGTTGCCGAGCACCTCAGAACCCAAGAGGAAATGGCCGCCTATCTTGAAGC
CTGCCTTGAAGAAGCAAACGGCGACGCGGCTTTTATCGCCAAGGCGCTGGGTGACATCGCTCGCGCCAAAGGCATGTCAC
AGGTCGCCCGAGATGCCGGGCTATCTCGCGAGAGTCTCTACAAGGCGCTTTCCGGCGACCGCAGCCCCGGCTTCGACACT
ATTCTCAAGGTCGTCGGAGCGCTGGGGCTGAAGCTGCATGCGCAGGCTAACCATGGGTGA
ATGACCAAAACCGCTACCACCCGCTACGACGTTGCCGAGCACCTCAGAACCCAAGAGGAAATGGCCGCCTATCTTGAAGC
CTGCCTTGAAGAAGCAAACGGCGACGCGGCTTTTATCGCCAAGGCGCTGGGTGACATCGCTCGCGCCAAAGGCATGTCAC
AGGTCGCCCGAGATGCCGGGCTATCTCGCGAGAGTCTCTACAAGGCGCTTTCCGGCGACCGCAGCCCCGGCTTCGACACT
ATTCTCAAGGTCGTCGGAGCGCTGGGGCTGAAGCTGCATGCGCAGGCTAACCATGGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|