Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3391981..3392599 Replicon chromosome
Accession NZ_CP058831
Organism Shigella flexneri strain STLE4

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag HZT21_RS16515 Protein ID WP_001291435.1
Coordinates 3392381..3392599 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag HZT21_RS16510 Protein ID WP_000344800.1
Coordinates 3391981..3392355 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZT21_RS16500 (3387070) 3387070..3388263 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HZT21_RS16505 (3388286) 3388286..3391435 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
HZT21_RS16510 (3391981) 3391981..3392355 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
HZT21_RS16515 (3392381) 3392381..3392599 + 219 WP_001291435.1 HHA domain-containing protein Toxin
HZT21_RS16520 (3392771) 3392771..3393322 + 552 WP_000102564.1 maltose O-acetyltransferase -
HZT21_RS16525 (3393438) 3393438..3393908 + 471 WP_000136192.1 YlaC family protein -
HZT21_RS16530 (3394072) 3394072..3395622 + 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
HZT21_RS16535 (3395664) 3395664..3396017 - 354 WP_000878140.1 DUF1428 domain-containing protein -
HZT21_RS16545 (3396396) 3396396..3396707 + 312 WP_000409911.1 MGMT family protein -
HZT21_RS16550 (3396738) 3396738..3397310 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T167617 WP_001291435.1 NZ_CP058831:3392381-3392599 [Shigella flexneri]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T167617 NZ_CP075192:c1010825-1009926 [Ferribacterium limneticum]
ATGAAAAAGGATCTCGCCACATCAGTCAGGGCGCGCTTGCTGAATACCGCGAAAGCACAAGGCGCGGATTTCAACCAGAT
ACTGGTGCGCTTTGCATTGGAGCGAATCCTTTACCGGTTGAGCCAGTCGGCGTACGCCGATCACTTTCTGCTCAAGGGGG
CACTGCTCTTCACACTGTGGTATGACATGCCCCACCGGAGTACGAGGGATGCCGATCTTCTCGGTTTTGGGGCAAGCGAT
CTCGAATCGATAGCCCGGACCTTCCATGACATCGCCAGCATTGAGGTAGCGGATGGGATTGTCTTCGATCCAGCCTCTGT
CAGCGTCGAGGAAATCCGCAAGGATGCAGGCTATGCCGGAGCCCGCGTTCTGATCACCGCTGAAATTGCCAAGGCACGCT
GCAAAACGCAGATCGACATCGGCTTCGGAGATGCGGTCACCCCCGGTCCGGTGCACGCAGCCTATCCGGTTCTGATCGAC
GACTTGCCCGCGCCTCAACTACGGACCAACCCCGTCTATACGGTCATCGCCGAAAAACTGCATGCCATCGCCCTACTCGG
CATGACCAACAGCCGCTTGAAGGATTACCTGGATATTTGGGTGTTGCTTGATCGCGAGGTGCTGAATGCCAATACGCTGG
CAAAGGCAATCGCCGCAACCTTCATCCGGCGAGGCATGCCGCTCCCGGTCGTCTTGCCTGTTGGCCTGACAGATGAATTC
GCAACCGACACATCGCGTCAGGCAATGTGGCAAGCATTTCTGAAAAAGAACGAAATTGTCATGGCCCCACTGCCTGAGGT
GGTGGCAAAGCTTCGGACAACGCTGGCGCCGATTCTCATTCAAGCCGCGAGTATTCAAGCCACCGGGGGATCGGATAAAT
CATTACAGAGTGCGCCGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT167617 WP_000344800.1 NZ_CP058831:3391981-3392355 [Shigella flexneri]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT167617 NZ_CP075192:c1011448-1010822 [Ferribacterium limneticum]
ATGGAACAAACTTGGCCAATCATGAGCCCTAACACCCACACCCAACGAGTCCTGGACCTGGCCCGCCAGAAGGGAACGCT
GCGTTCGCGCGACCTTGATGAAATCGGTGCCCCCCGAGTGATCCTGACGCGCCTGACGACCACTGGCCTGCTGGAAAAAA
CGGGGCGGGGAATCTATCGACTCCCGGACAGTCAGGTTTCTGAACATGAAAACCTGCTCGCCATCGCAACCAAAGTGCCG
CAAGCAGTCTTCTGCCTGCTCACCGCCTTGCAGTTTCATGAACTCACCACCCAGCTGCCGCGCCGGATATGGATTGCAAT
GCCACGCGGAAGCCACACACCGAAGATCAACTACCCGCCATTGAAGATGGTCCAGTTTGCGGGAGATTCCTACGCTGAAG
GGATTGAGGTCGTGGAGCGCGATCAGGTCAAGCTTCGGATTTATTGTGTTGCGAAGACCATAGCCGACTGTTTCAAGCAC
CGCAACAAAATCGGGCTCGACGTTGCGCTGGAGGCATTGAAGGATGCAAAGGCACAGAAAAAGGCCTCTGCCGACGAACT
CTGGCGCTTCGCCAAAATTTGCCGGGTTGCCAATGTGATGCGTCCCTATCTTGAGGCGCTCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References