Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2257013..2258601 Replicon chromosome
Accession NZ_CP058831
Organism Shigella flexneri strain STLE4

Toxin (Protein)


Gene name hipA Uniprot ID S1ELM3
Locus tag HZT21_RS10965 Protein ID WP_001125439.1
Coordinates 2257279..2258601 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag HZT21_RS10960 Protein ID WP_001301023.1
Coordinates 2257013..2257279 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZT21_RS10960 (2257013) 2257013..2257279 + 267 WP_001301023.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
HZT21_RS10965 (2257279) 2257279..2258601 + 1323 WP_001125439.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
HZT21_RS10970 (2258913) 2258913..2259121 + 209 Protein_2152 AraC family transcriptional regulator -
HZT21_RS10975 (2259376) 2259376..2260602 + 1227 Protein_2153 fimbria/pilus outer membrane usher protein -
HZT21_RS10980 (2260616) 2260616..2261146 + 531 WP_000876763.1 fimbrial protein -
HZT21_RS10985 (2261159) 2261159..2261662 + 504 WP_000825452.1 fimbrial protein -
HZT21_RS10990 (2261721) 2261721..2262635 + 915 WP_000520662.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2257013..2269822 12809


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-401)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49275.82 Da        Isoelectric Point: 8.2482

>T167615 WP_001125439.1 NZ_CP058831:2257279-2258601 [Shigella flexneri]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVTHPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NAERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVESNVLRLHGRLSREYGSK

Download         Length: 1323 bp

>T167615 NZ_CP075192:88723-89367 [Ferribacterium limneticum]
ATGATTTACAAAAATCTGAATCCGGAAAAAGCCCTGATCTGGCGCATCGTCCACCGCGATAACCTGCCGTGGATTCTGGA
CAATGGTTTGCACTGCCGGAATTCACAGTTTCAGGATCCGAATTTTGTGAATATCGGCAATCCGGAGTTGATCGACAAGC
GGGCGCACCGCGGTGTGCCCATTACTCCAGGTGGCACTCTCAGCGACTATGTCCCGTTCTACTTCACGCCGTTTTCGGTG
ATGATGAAGAATATTCACTCTGGCTGGGGAGGAATACGTCAGCGCAGCAATGCAGAGATCGTTATTCTCGTTTCCAGCCT
GCGCCGGGTGCAGGAACAAGGGATTCCTTTCTTGTTTACCAATGGCCACGCATATCCGCCAGACACCCGGTTTTTCAATG
ACTTGAGTGATCTTTCTGTAATTGATTGGGGTATCCTTCAAAAACGCGATTTCAAACGTGATCTGGATGACCCGAAAAAG
CTGGAACGCTATCAGGCGGAAGCCTTGATTCACCAGCACCTGCCAGTCTCTGGCTTGGTGGGCGCAGTCTGCTATACCGA
AGCGATCAAGTCGGATATTGAGCAACAGATTCTTGCGCGCGGCCTGTCATTGCAGGTCGTTGCCCGTACCGAGTGGTATT
TTTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10016.38 Da        Isoelectric Point: 6.2267

>AT167615 WP_001301023.1 NZ_CP058831:2257013-2257279 [Shigella flexneri]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDAKNASPES
TEQQNLEW

Download         Length: 267 bp

>AT167615 NZ_CP075192:89367-90449 [Ferribacterium limneticum]
ATGATACGTTTTACACAAGGCAACCTTCTTGAATCCCAGGCTGAAGCACTGGTAAATACCGTCAACACCGTTGGTGTGAT
GGGGAAGGGGATCGCCCTGATGTTCAAGGAGCGGTTTTCCGCGAATTTCCTGGCTTATGCTGCTGCCTGCAAAGCCAAAC
AGGTGCAGACCGGCAAAATGTTTGTCACGGAAGTTCATGAACTGGGAGGTCCGCGCTGGATCGTCAACTTTCCAACCAAA
AGGCACTGGAAGGCCCCGTCGGAACTGGTCTGGGTGAAGGATGGCTTACAGGACTTGCGTCGTTTCCTTCTCGAGAAGAA
GGTGAAATCCATCGCTATTCCACCGTTGGGGGCTGGCAATGGCGGCTTGGAGTGGCCTGAAGTGCGCGAGCAGATCAAGC
TTGCGCTGGAGGATCTGGACGTCGAGATTCTGGTCTTTGAGCCAACTTCGCAGTATCAAAACGTGGCCAAGCGCAGTGGT
ACCGAGAAGCTCACCCCAGCGCGTGCACTGATTGCTGAGTTGGTGCGCCGTTACTGGGTGCTTGGGATGGAGTGTAGCCT
GCTGGAAATTCAGAAACTGGCTTGGTTTATGGAGCGAGCGATTGAACGCTTCTCGCTGGAAAATAACCCGCTGAAATTGG
AATTCAAAGCACATATCTATGGGCCGTTTACGCCCAAGCTAAATTTTGTTCTCGACAATTTGGATGGCAGTTATCTGCAC
TGCGACAAGCGTATCAGTGATGCGAGTCCGCTCGACGTAATCTGGTTTGATGACTCGCGCAAGGATCTGGTCCAGGCCTA
CTTGAAGACTGAAGCTAGGCAATATTCCGAAGCACTGGAATACGTTGGCGAGTTAATCGACGGTTTTGAGTCGCCTTTTG
GCATGGAGTTACTGGCCACCGTGGATTGGCTGTTAACGCGAGAAAACGCCGAGCCTACGGTTACGGGCATTCGTCAGGCA
CTTGGTGCTTGGCCAGCGGGTGCGGCTGCGGCTGCACGCAAGTTGCGTCTGTTCGATGAGCGATCAGTTGGATTTGCATT
GGAGCGCCTGACAAAAGCGCAACCAGTTCCGCTTGCGGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5K98
PDB 3TPV
PDB 3DNV
PDB 3TPD
PDB 3HZI
PDB 3FBR
PDB 4YG7
PDB 3TPE
PDB 2WIU
PDB 3DNT
PDB 3TPB
PDB 3TPT
PDB 3DNU

Antitoxin

Source ID Structure

References