167599

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 11365..11887 Replicon plasmid unnamed2
Accession NZ_CP058830
Organism Shigella flexneri strain STLE3

Toxin (Protein)


Gene name relE Uniprot ID G3CAN5
Locus tag HZT20_RS23840 Protein ID WP_000220560.1
Coordinates 11365..11646 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G3CAG1
Locus tag HZT20_RS23845 Protein ID WP_000121743.1
Coordinates 11636..11887 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZT20_RS23810 (HZT20_23640) 6735..7241 + 507 WP_079889766.1 recombinase family protein -
HZT20_RS23815 (HZT20_23645) 7424..8284 + 861 WP_000027057.1 broad-spectrum class A beta-lactamase TEM-1 -
HZT20_RS23825 (HZT20_23660) 9654..9905 + 252 Protein_9 IS200/IS605 family transposase -
HZT20_RS23830 (HZT20_23665) 10097..10291 - 195 WP_053273080.1 hypothetical protein -
HZT20_RS23840 (HZT20_23675) 11365..11646 - 282 WP_000220560.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HZT20_RS23845 (HZT20_23680) 11636..11887 - 252 WP_000121743.1 plasmid stabilization protein Antitoxin
HZT20_RS23850 (HZT20_23685) 13121..13957 + 837 WP_001050931.1 RepB family plasmid replication initiator protein -
HZT20_RS23855 (HZT20_23690) 13997..14443 + 447 Protein_15 hypothetical protein -
HZT20_RS23860 (HZT20_23695) 14580..14936 + 357 WP_000456533.1 DNA distortion polypeptide 3 -
HZT20_RS23865 (HZT20_23700) 14933..15910 - 978 WP_024245156.1 hypothetical protein -
HZT20_RS23870 (HZT20_23705) 15935..16216 - 282 WP_001185482.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid floR / blaTEM-1A / tet(A) - 1..24419 24419


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11005.83 Da        Isoelectric Point: 10.5938

>T167599 WP_000220560.1 NZ_CP058830:c11646-11365 [Shigella flexneri]
MTYELAFDRRALKEWQKLGHTIREQFKKKLAERLENPRVPAARLHGHADRYKIKLRASGYRLVYQVIDEKVVLLVIAVGR
RESSEVYQIADLR

Download         Length: 282 bp

>T167599 NZ_CP075188:c2989504-2989193 [Quatrionicoccus australiensis]
ATGACAGAGAAATTTACCCGTTGGGACCCTGTTGATCAGTTGCTGAGTGGTGAAGACATGGCCCTCTACCTTGACGCCTG
CCTAGACGAAGACAACGGCGATGGAAGTGTGGTGCGTGCCGCTCTTAACGACATCGCCAGAGCGCAAGGCATGAGCCAGC
TTGCCCGTGACACTGGGCTGACTCGAGAGGGCCTGTACAAAGCATTGTCGCCAGCCGGCAATCCGGAGTTTTCGACGATC
CTGAAGGTTATCAAGGCGCTGAAAATTAAATTACATGCTACGCCTGGTGGTGACCACTTGGTCGCTGCCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9194.43 Da        Isoelectric Point: 4.1683

>AT167599 WP_000121743.1 NZ_CP058830:c11887-11636 [Shigella flexneri]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKNPEIVKVNL
DDL

Download         Length: 252 bp

>AT167599 NZ_CP075188:c2989800-2989501 [Quatrionicoccus australiensis]
ATGATCGAAATCATCCAGAGCGAGACCTTCGCCCGGTGGCTGGGCAAGCTAAAGGACCGGTCCGCGGTTATGCGGATCAA
CGCCCGGCTTCGTCGCTTGACGGAGACCGGCAACTTCGGCGACGTGAAGCCTGTTCGCGAAGGTGTTAGCGAAATGAGGA
TCGACTACGGCCCTGGTTATCGTCTCTACTTTGTCCAGAACGGTCCGGTGTTGGTGGTCTTGCTCGCCGGTGGCGACAAG
AATACTCAGGATGCCGACATCAAACGTGCCATCGATATTTCCAAGGAGTGGAAGCCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G3CAN5

Antitoxin

Source ID Structure
AlphaFold DB A0A3S5I301

References