167597

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4314391..4314888 Replicon chromosome
Accession NZ_CP058828
Organism Shigella flexneri strain STLE3

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag HZT20_RS20720 Protein ID WP_001173343.1
Coordinates 4314391..4314564 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag HZT20_RS20725 Protein ID WP_000398619.1
Coordinates 4314592..4314888 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZT20_RS20710 (4311061) 4311061..4312518 + 1458 WP_000856829.1 dipeptide/tripeptide permease DtpC -
HZT20_RS20715 (4312755) 4312755..4314272 + 1518 WP_001295074.1 lysine--tRNA ligase -
HZT20_RS20720 (4314391) 4314391..4314564 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
HZT20_RS20725 (4314592) 4314592..4314888 - 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
HZT20_RS20730 (4315115) 4315115..4315387 - 273 WP_000405651.1 GNAT family N-acetyltransferase -
HZT20_RS20735 (4315399) 4315399..4315629 - 231 WP_000371704.1 4Fe-4S mono-cluster protein YjdI -
HZT20_RS20740 (4315810) 4315810..4317441 + 1632 WP_001216477.1 sensor histidine kinase -
HZT20_RS20745 (4317438) 4317438..4318157 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T167597 WP_001173343.1 NZ_CP058828:c4314564-4314391 [Shigella flexneri]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

>T167597 NZ_CP075183:c5573197-5572919 [Hydrogenophaga taeniospiralis]
ATGATCCAGTCGTTCAAGTGTGGTGATGCGCAGGCGCTTTATGAGACCGGCAAGTCCAGGCGCTTTGTCAACTTCAAGGA
AGTGGCTGAGCGCAAACTGACCCAGTTGGCCGCAGCCACCACGCTGGAATTTCTGAGGTCTCCGCCGGGTAACCACCTTG
AGGCCTTGTCGGGTGACCGCGTCGGGCAGCACAGCGTGCGCATCAACAAACAATGGCGGGTGTGTTTTGTTTGGACCGCA
GAAGGTCCAGCCGATGTGGAGATCGTTGACTATCACTGA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT167597 WP_000398619.1 NZ_CP058828:c4314888-4314592 [Shigella flexneri]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp

>AT167597 NZ_CP075183:c5572896-5572594 [Hydrogenophaga taeniospiralis]
ATGATCAAGAACGGAATGCGGCCGGTGCACCCCGGCGAGGTTTTGCGCGAGGATTTTTTAAAACCGCTGGGCATGAGTGC
CAATGCGCTTTCCAGGGCGCTGCATGTGCCGGCCGGGCGGGTCAATGACATCGTGCTGGAGCGGCGTGGCGTGACGCCAG
ACACCGCCTTGCGCCTGGCCCGCTACTTTGGCGGCGATGCCCAGTCGTGGCTCAATCTTCAGCAGATGCACGACCTGAAG
CTGGCCGAGCGGGCCATGGCCAGTCGGATCGAGGCTGAGATCGAGCCGATGGCGGCGCATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBH6

References