Detailed information of TA system TA167596

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 4110822..4111636
• Replicon: chromosome
• Accession: NZ_CP058828
• Organism: Shigella flexneri strain STLE3

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: S1PA82
• Locus tag: HZT20_RS19670
• Protein ID: WP_001054376.1
• Coordinates: 4110822..4111079 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: B7MMJ3
• Locus tag: HZT20_RS19675
• Protein ID: WP_001338189.1
• Coordinates: 4111091..4111636 (+)
• Length: 182 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HZT20_RS19645 (4106110)	4106110..4107216	+	1107	WP_001299704.1	N-acetylneuraminate epimerase	-
HZT20_RS19650 (4107281)	4107281..4108261	+	981	WP_061350442.1	sialate O-acetylesterase	-
HZT20_RS19655 (4108371)	4108371..4108576	+	206	Protein_3860	HNH endonuclease	-
HZT20_RS19660 (4108844)	4108844..4110084	-	1241	Protein_3861	helicase YjhR	-
HZT20_RS19665 (4110200)	4110200..4110331	+	132	WP_001309182.1	hypothetical protein	-
HZT20_RS19670 (4110822)	4110822..4111079	+	258	WP_001054376.1	YjhX family toxin	Toxin
HZT20_RS19675 (4111091)	4111091..4111636	+	546	WP_001338189.1	N-acetyltransferase	Antitoxin
HZT20_RS19680 (4111692)	4111692..4112438	+	747	WP_000354251.1	class I SAM-dependent methyltransferase	-
HZT20_RS19685 (4112607)	4112607..4112825	+	219	Protein_3866	hypothetical protein	-
HZT20_RS19690 (4112863)	4112863..4112979	+	117	Protein_3867	VOC family protein	-
HZT20_RS19695 (4113224)	4113224..4114345	+	1122	WP_000010829.1	M42 family metallopeptidase	-
HZT20_RS19700 (4114342)	4114342..4114620	+	279	WP_000722973.1	PTS sugar transporter subunit IIB SgcB	-
HZT20_RS19705 (4114632)	4114632..4115945	+	1314	WP_000460843.1	PTS sugar transporter subunit IIC SgcC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fimC / fimI / fimA / fimE / fimB	4099845..4119860	20015

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9734.29 Da
• Isoelectric Point: 11.0090

>T167596 WP_001054376.1 NZ_CP058828:4110822-4111079 [Shigella flexneri]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Nucleotide

• Length: 258 bp

>T167596 NZ_CP075183:c4672691-4672308 [Hydrogenophaga taeniospiralis]
ATGCAAAAGCAAGCGCGCAAACCCATCAAATGGGTCAGTTCCGCCAAGCGTGATCTGGATGCAATGCCGGAGGAGGTCAA
GGATATCTTCGGTCATGCCATCGACTTGGCTCAAGCCGGTGGCAAGCACAAGGATTCGAAAGTGCTGACGGGTTTCGGCT
CGGCCGGCGTGCTGGAGGTCGTCGAGGACCATCAGGGTGACACCTTCCGGGCTGTCTACACCGTCAAGTTCGCCGGTTGG
GTCTATGTCCTGCACTGCTTTCAGAAGAAGTCCAAAAGCGGCATCGCCACGCCAAAGCAGGACATGGACTTGATCAATAC
CCGCCTGAAAGCCGCGAAGCAGGATTTCGAAGCATGGCAGGCGCAGCAAGGAGTACGCAAATGA

Antitoxin

Protein

• Length: 182 a.a.
• Molecular weight: 19986.92 Da
• Isoelectric Point: 6.3277

>AT167596 WP_001338189.1 NZ_CP058828:4111091-4111636 [Shigella flexneri]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVTSLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Nucleotide

• Length: 546 bp

>AT167596 NZ_CP075183:c4672311-4671982 [Hydrogenophaga taeniospiralis]
ATGAATGGGCACAACGAAATCACGATCGAAGAAGGTGGCACGAATGTCTATGCCGACCTGGGTTACACCGACGCTGCGGA
GATGCAGCGTAAATCCCAGCTCGCGGGCGAGATCGCCCGTGCGATCAAGGCACGTCGCCTGACGCAAGAAGGTGCGGCGA
CGCTGCTGGGCATTGATCAATCCAAGGTCTCGCGCATCACGCGCGGTCAGTTCCGCGGTGTCAGCGAAGCCAAGCTGCTC
GAGCTGGTGGCTAGACTGGGACACGATGTGAAGATCGTGGTTGGCCCGGTGCGCCGGCGCGCCGGCAAGATTGAGCTGCA
ATTTGCCTGA

Structures

Toxin

• AlphaFold DB: S1PA82

Antitoxin

• AlphaFold DB: A0A0E2KXJ3