Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4110822..4111636 Replicon chromosome
Accession NZ_CP058828
Organism Shigella flexneri strain STLE3

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag HZT20_RS19670 Protein ID WP_001054376.1
Coordinates 4110822..4111079 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID B7MMJ3
Locus tag HZT20_RS19675 Protein ID WP_001338189.1
Coordinates 4111091..4111636 (+) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZT20_RS19645 (4106110) 4106110..4107216 + 1107 WP_001299704.1 N-acetylneuraminate epimerase -
HZT20_RS19650 (4107281) 4107281..4108261 + 981 WP_061350442.1 sialate O-acetylesterase -
HZT20_RS19655 (4108371) 4108371..4108576 + 206 Protein_3860 HNH endonuclease -
HZT20_RS19660 (4108844) 4108844..4110084 - 1241 Protein_3861 helicase YjhR -
HZT20_RS19665 (4110200) 4110200..4110331 + 132 WP_001309182.1 hypothetical protein -
HZT20_RS19670 (4110822) 4110822..4111079 + 258 WP_001054376.1 YjhX family toxin Toxin
HZT20_RS19675 (4111091) 4111091..4111636 + 546 WP_001338189.1 N-acetyltransferase Antitoxin
HZT20_RS19680 (4111692) 4111692..4112438 + 747 WP_000354251.1 class I SAM-dependent methyltransferase -
HZT20_RS19685 (4112607) 4112607..4112825 + 219 Protein_3866 hypothetical protein -
HZT20_RS19690 (4112863) 4112863..4112979 + 117 Protein_3867 VOC family protein -
HZT20_RS19695 (4113224) 4113224..4114345 + 1122 WP_000010829.1 M42 family metallopeptidase -
HZT20_RS19700 (4114342) 4114342..4114620 + 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
HZT20_RS19705 (4114632) 4114632..4115945 + 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimC / fimI / fimA / fimE / fimB 4099845..4119860 20015


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T167596 WP_001054376.1 NZ_CP058828:4110822-4111079 [Shigella flexneri]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

>T167596 NZ_CP075183:c4672691-4672308 [Hydrogenophaga taeniospiralis]
ATGCAAAAGCAAGCGCGCAAACCCATCAAATGGGTCAGTTCCGCCAAGCGTGATCTGGATGCAATGCCGGAGGAGGTCAA
GGATATCTTCGGTCATGCCATCGACTTGGCTCAAGCCGGTGGCAAGCACAAGGATTCGAAAGTGCTGACGGGTTTCGGCT
CGGCCGGCGTGCTGGAGGTCGTCGAGGACCATCAGGGTGACACCTTCCGGGCTGTCTACACCGTCAAGTTCGCCGGTTGG
GTCTATGTCCTGCACTGCTTTCAGAAGAAGTCCAAAAGCGGCATCGCCACGCCAAAGCAGGACATGGACTTGATCAATAC
CCGCCTGAAAGCCGCGAAGCAGGATTTCGAAGCATGGCAGGCGCAGCAAGGAGTACGCAAATGA

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19986.92 Da        Isoelectric Point: 6.3277

>AT167596 WP_001338189.1 NZ_CP058828:4111091-4111636 [Shigella flexneri]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVTSLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp

>AT167596 NZ_CP075183:c4672311-4671982 [Hydrogenophaga taeniospiralis]
ATGAATGGGCACAACGAAATCACGATCGAAGAAGGTGGCACGAATGTCTATGCCGACCTGGGTTACACCGACGCTGCGGA
GATGCAGCGTAAATCCCAGCTCGCGGGCGAGATCGCCCGTGCGATCAAGGCACGTCGCCTGACGCAAGAAGGTGCGGCGA
CGCTGCTGGGCATTGATCAATCCAAGGTCTCGCGCATCACGCGCGGTCAGTTCCGCGGTGTCAGCGAAGCCAAGCTGCTC
GAGCTGGTGGCTAGACTGGGACACGATGTGAAGATCGTGGTTGGCCCGGTGCGCCGGCGCGCCGGCAAGATTGAGCTGCA
ATTTGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB A0A0E2KXJ3

References