Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 2284254..2284780 | Replicon | chromosome |
| Accession | NZ_CP058828 | ||
| Organism | Shigella flexneri strain STLE3 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | HZT20_RS10920 | Protein ID | WP_000323025.1 |
| Coordinates | 2284493..2284780 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | HZT20_RS10915 | Protein ID | WP_000534858.1 |
| Coordinates | 2284254..2284493 (+) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HZT20_RS10890 (2279588) | 2279588..2280077 | + | 490 | Protein_2139 | class I SAM-dependent methyltransferase | - |
| HZT20_RS10895 (2280555) | 2280555..2280976 | + | 422 | Protein_2140 | hypothetical protein | - |
| HZT20_RS10900 (2281611) | 2281611..2282952 | + | 1342 | Protein_2141 | ISNCY family transposase | - |
| HZT20_RS10905 (2283389) | 2283389..2283721 | - | 333 | WP_001317460.1 | FlxA-like family protein | - |
| HZT20_RS10910 (2283924) | 2283924..2284229 | - | 306 | WP_001326990.1 | protein YdfV | - |
| HZT20_RS10915 (2284254) | 2284254..2284493 | + | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| HZT20_RS10920 (2284493) | 2284493..2284780 | + | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| HZT20_RS10925 (2284852) | 2284852..2285007 | + | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| HZT20_RS10930 (2285224) | 2285224..2285475 | + | 252 | WP_000980994.1 | protein Rem | - |
| HZT20_RS10935 (2285542) | 2285542..2285820 | + | 279 | WP_012304870.1 | hypothetical protein | - |
| HZT20_RS10940 (2285822) | 2285822..2286871 | + | 1050 | WP_061350716.1 | DUF968 domain-containing protein | - |
| HZT20_RS10945 (2286885) | 2286885..2287637 | + | 753 | WP_001047135.1 | antitermination protein | - |
| HZT20_RS10950 (2287915) | 2287915..2288004 | - | 90 | WP_120795389.1 | hypothetical protein | - |
| HZT20_RS10955 (2288059) | 2288059..2288271 | - | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| HZT20_RS10960 (2288572) | 2288572..2288787 | + | 216 | WP_000066484.1 | cold shock-like protein CspB | - |
| HZT20_RS10965 (2289151) | 2289151..2289321 | - | 171 | WP_211180497.1 | putative zinc-binding protein YnfU | - |
| HZT20_RS10970 (2289541) | 2289541..2289756 | + | 216 | WP_000839590.1 | phage lysis protein EssD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2265950..2319647 | 53697 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T167592 WP_000323025.1 NZ_CP058828:2284493-2284780 [Shigella flexneri]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T167592 NZ_CP075176:c5779398-5779120 [Pseudomonas aeruginosa]
ATGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCATCATGCGGCTACGGAGCTTCGAGACTTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGTGGGCCAACATAGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA
ATGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCATCATGCGGCTACGGAGCTTCGAGACTTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGTGGGCCAACATAGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT167592 WP_000534858.1 NZ_CP058828:2284254-2284493 [Shigella flexneri]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT167592 NZ_CP075176:c5779108-5778803 [Pseudomonas aeruginosa]
ATGGCTACCAATGGTATGCGCCCCATCCATCCTGGGGAAATATTACGCGATGAGTTTCTGATGGAGTTGGATATCTCTCC
AGCTGCCCTAGCACGCGCTTTGAAAGTCTCCGCTCCGACAGTGAACGATATCGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGTCTGGGGCGTTACTTTGATACGTCCGCTCAGTTCTGGATGAATCTCCAGAGTGAGTACTCGTTAGCA
ACTGCTTATGCGGCGAATGGCGAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCACGGATAG
ATGGCTACCAATGGTATGCGCCCCATCCATCCTGGGGAAATATTACGCGATGAGTTTCTGATGGAGTTGGATATCTCTCC
AGCTGCCCTAGCACGCGCTTTGAAAGTCTCCGCTCCGACAGTGAACGATATCGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGTCTGGGGCGTTACTTTGATACGTCCGCTCAGTTCTGGATGAATCTCCAGAGTGAGTACTCGTTAGCA
ACTGCTTATGCGGCGAATGGCGAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCACGGATAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|