167580

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 929590..930244 Replicon chromosome
Accession NZ_CP058828
Organism Shigella flexneri strain STLE3

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag HZT20_RS04430 Protein ID WP_000244777.1
Coordinates 929837..930244 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag HZT20_RS04425 Protein ID WP_000354046.1
Coordinates 929590..929856 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZT20_RS04400 (924759) 924759..925502 + 744 WP_000951964.1 SDR family oxidoreductase -
HZT20_RS04405 (925559) 925559..926992 - 1434 WP_001336277.1 6-phospho-beta-glucosidase BglA -
HZT20_RS04410 (927037) 927037..927348 + 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
HZT20_RS04415 (927512) 927512..928171 + 660 WP_000250274.1 hemolysin III family protein -
HZT20_RS04420 (928367) 928367..929347 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
HZT20_RS04425 (929590) 929590..929856 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
HZT20_RS04430 (929837) 929837..930244 + 408 WP_000244777.1 protein YgfX Toxin
HZT20_RS04435 (930284) 930284..930805 - 522 WP_001055874.1 flavodoxin FldB -
HZT20_RS04440 (930917) 930917..931813 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
HZT20_RS04445 (931838) 931838..932548 + 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HZT20_RS04450 (932554) 932554..934287 + 1734 WP_000813200.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T167580 WP_000244777.1 NZ_CP058828:929837-930244 [Shigella flexneri]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T167580 NZ_CP058828:929837-930244 [Shigella flexneri]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT167580 WP_000354046.1 NZ_CP058828:929590-929856 [Shigella flexneri]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT167580 NZ_CP058828:929590-929856 [Shigella flexneri]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QD57

References