Detailed information of TA system TA167579

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/Doc-RelB
• Location: 857652..858250
• Replicon: chromosome
• Accession: NZ_CP058828
• Organism: Shigella flexneri strain STLE3

Toxin (Protein)

• Gene name: doc
• Uniprot ID: L4J396
• Locus tag: HZT20_RS04060
• Protein ID: WP_001603496.1
• Coordinates: 857873..858250 (+)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: L4J1C0
• Locus tag: HZT20_RS04055
• Protein ID: WP_001603498.1
• Coordinates: 857652..857873 (+)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HZT20_RS04040 (853252)	853252..853932	+	681	WP_032187672.1	fimbrial assembly chaperone	-
HZT20_RS04045 (853950)	853950..856436	+	2487	WP_096187598.1	fimbrial biogenesis outer membrane usher protein	-
HZT20_RS04050 (856448)	856448..857467	+	1020	WP_021824042.1	fimbrial protein	-
HZT20_RS04055 (857652)	857652..857873	+	222	WP_001603498.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
HZT20_RS04060 (857873)	857873..858250	+	378	WP_001603496.1	type II toxin-antitoxin system death-on-curing family toxin	Toxin
HZT20_RS04065 (858360)	858360..858573	-	214	Protein_802	transposase	-
HZT20_RS04070 (858759)	858759..860021	-	1263	WP_021824043.1	integrase arm-type DNA-binding domain-containing protein	-
HZT20_RS04080 (860400)	860400..861107	-	708	WP_000234517.1	DUF554 domain-containing protein	-
HZT20_RS04085 (861260)	861260..861343	+	84	WP_211180506.1	protein YqgH	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	849694..860021	10327

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Death on curing protein (3-119)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-51)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 13477.24 Da
• Isoelectric Point: 6.2257

>T167579 WP_001603496.1 NZ_CP058828:857873-858250 [Shigella flexneri]
MRHISPEELIAIHDANISRYGGLPGMSDSGRAEAIIGRVQARVAYEEITDLFEVSATYLVATARGHIFNDANKRTALNSA
LLFLRRNGVQVYDSPELAELTVGAATGEVSVSTVVATLRRLYGTA

Nucleotide

• Length: 378 bp

>T167579 NZ_CP075174:c1966618-1966340 [Salmonella enterica subsp. houtenae serovar 45:g,z51:-]
ATGATTAAAAGCTTCAGACATAAGGGACTGAACAAGTTCTATCAAAAAGGCGACAGCAGCGGTTTAGAACAATCACTGGT
CCCGCGCCTGAAAAACAGGTTATCCATGCTGGATGCAGCAAAGACAATTGATTTCCTGAATCAGCAAGGGTACGACCTTC
ATGAGCTTAAAGGCGATCGTGCTGAAACGTGGTCCATAAAAGTTTCTGGTAACTGGCGTCTGACGTTTATCTTTGAAAAC
GGTGACGTCTACGTTCTCAACCTGGAGGATTATCACTAA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8190.24 Da
• Isoelectric Point: 6.3159

>AT167579 WP_001603498.1 NZ_CP058828:857652-857873 [Shigella flexneri]
MQSINFRTARSNLTEVLNNVEAGEEVEITRRGREPAVIVSKATFEAYKKAALDAEFASLFDTLDTTNKKLVNR

Nucleotide

• Length: 222 bp

>AT167579 NZ_CP075174:c1966340-1966056 [Salmonella enterica subsp. houtenae serovar 45:g,z51:-]
ATGGCTATGTTCGATCCTGCTTACCCTGGCGAAATCATTGCCGAAATTCTGGAAGACCAGGGCGTAAGCCTGCGTCAGTT
TGCTGTAGCTATGAATATTGCGCCATCAACCGCCAGCCGTATTCTGAACGGTAAAGTAAGTATCACGCCAGAAATGGCGG
TTAAGCTGGCTATCGTTCTTGGCGGCGATGCCGAAAGCTGGCTTAACCTTCAGAATAACTACAGTCTGTCGCAGGCACGT
AAAACAGTGGATATAACTCATGTTCACCGTCTGTCTTTTGCCTGA

Structures

Toxin

• AlphaFold DB: L4J396

Antitoxin

• AlphaFold DB: L4J1C0