Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 478..1000 Replicon plasmid unnamed1
Accession NZ_CP058827
Organism Shigella flexneri strain STLE1

Toxin (Protein)


Gene name relE Uniprot ID G3CAN5
Locus tag HZT18_RS21925 Protein ID WP_000220560.1
Coordinates 478..759 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G3CAG1
Locus tag HZT18_RS21930 Protein ID WP_000121743.1
Coordinates 749..1000 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZT18_RS21920 (HZT18_21720) 9..332 - 324 WP_001181903.1 hypothetical protein -
HZT18_RS21925 (HZT18_21725) 478..759 - 282 WP_000220560.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HZT18_RS21930 (HZT18_21730) 749..1000 - 252 WP_000121743.1 plasmid stabilization protein Antitoxin
HZT18_RS21935 (HZT18_21735) 2256..3092 + 837 WP_001050931.1 RepB family plasmid replication initiator protein -
HZT18_RS21940 (HZT18_21740) 3132..3578 + 447 WP_001074386.1 hypothetical protein -
HZT18_RS21945 (HZT18_21745) 3715..4068 + 354 WP_000876434.1 DNA distortion polypeptide 3 -
HZT18_RS21950 (HZT18_21750) 4128..5096 - 969 WP_077249520.1 IS5-like element IS903B family transposase -
HZT18_RS21955 (HZT18_21755) 5098..5391 - 294 WP_015060510.1 hypothetical protein -
HZT18_RS21960 (HZT18_21760) 5407..5637 - 231 WP_000051064.1 plasmid partition protein ParG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaTEM-176 / qnrS1 / tet(A) / floR / dfrA14 / aph(3')-Ia - 1..46569 46569


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11005.83 Da        Isoelectric Point: 10.5938

>T167576 WP_000220560.1 NZ_CP058827:c759-478 [Shigella flexneri]
MTYELAFDRRALKEWQKLGHTIREQFKKKLAERLENPRVPAARLHGHADRYKIKLRASGYRLVYQVIDEKVVLLVIAVGR
RESSEVYQIADLR

Download         Length: 282 bp

>T167576 NZ_CP075174:1795218-1795571 [Salmonella enterica subsp. houtenae serovar 45:g,z51:-]
GTGTGGACGATTAAAACAACGGATATGTTTGATCACTGGTTTTCCTCGCTCAATGATACCGATCGGGCCAGCGTGCTTGC
AGCGCTGTTGGTCCTGCGTGAAAAGGGGCCGGGTTTGTCCAGACCTTATGCCGATACGCTCAGAGGCTCCCGCTTTAGCA
ACATGAAAGAGTTGCGTATTCAAAGTCGGGGTGATCCGATACGGGCATTTTTCGCTTTTGATCCGACCCGTACCGGCATT
GTACTTTGTGCGGGAAATAAGGTCGGTAATGAAAAACGTTTTTACGATGAGATGCTCCCGGTTGCAGATCGGGAATTCAC
GAACTGGCTGAACATAATAAAAGAGAAGGAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9194.43 Da        Isoelectric Point: 4.1683

>AT167576 WP_000121743.1 NZ_CP058827:c1000-749 [Shigella flexneri]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKNPEIVKVNL
DDL

Download         Length: 252 bp

>AT167576 NZ_CP075174:1795576-1795878 [Salmonella enterica subsp. houtenae serovar 45:g,z51:-]
ATGGGCAGAACGCTGGAACAGCTTATTGCGGATGAAAAACCTGAAGTCGTGGCCGAAGCTCAGGCGATGGCGACGGACAT
CCTGCTCAACATTCACCTTGCCGAACTGCGCGAGAAAGTACAGAAAACGCAGGTCGAAATGGCGCAGATGCTGGGCATCA
GGCAACCTACTGTTGCCGGTATGGAAAAACCGGGGCGCGACCTGAAGCTTTCCACGCTGAAACGCTACGTTGAGGCGACC
GGCGGCAAGCTACGCCTTGATGTTGAACTGCCGGATGGTTCTCACTACGGATTTGTATTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G3CAN5

Antitoxin

Source ID Structure
AlphaFold DB A0A3S5I301

References