Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 3922023..3922618 Replicon chromosome
Accession NZ_CP058826
Organism Shigella flexneri strain STLE1

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag HZT18_RS19150 Protein ID WP_000239579.1
Coordinates 3922023..3922373 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag HZT18_RS19155 Protein ID WP_001223208.1
Coordinates 3922367..3922618 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZT18_RS19130 (3917469) 3917469..3918491 - 1023 WP_001295197.1 ABC transporter permease -
HZT18_RS19135 (3918505) 3918505..3920007 - 1503 WP_000205784.1 sugar ABC transporter ATP-binding protein -
HZT18_RS19140 (3920147) 3920147..3921103 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
HZT18_RS19145 (3921413) 3921413..3921943 + 531 WP_000055072.1 inorganic diphosphatase -
HZT18_RS19150 (3922023) 3922023..3922373 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
HZT18_RS19155 (3922367) 3922367..3922618 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
HZT18_RS19160 (3922830) 3922830..3923171 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
HZT18_RS19165 (3923174) 3923174..3926953 - 3780 WP_174784744.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T167574 WP_000239579.1 NZ_CP058826:c3922373-3922023 [Shigella flexneri]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T167574 NZ_CP075171:4093762-4094184 [Leptodesmis sichuanensis PKUAC-SCTA121]
ATGAAGTACCTGCTTGATACCTGTGTCATCTCTGAGCTAATCGCGAAATCTCCCAATCAGAAGGTGATTGACTGGGTTGA
TCAACTTGAAGAAATGCAGATCTATCTGAGTGTGGTGACGATCGGTGAAATTTGCAAAGGAATTGCCAAACTAACAGATT
CCCAACGTAAAAACGAATTAACTCACTGGCTGCATCAGGAATTATTGGTGCGCTTTGCCGATCGCATTCTCCCCATTGAT
GTAGAAGTTATGCTGACCTGGGGAGAGCTAACTGGAAATTTGGAACGAACGGGCAAAAAGATACCTGCCGTAGATTCCTT
AATTGCCGCGATCGCGCTGCAAAATCAGCTTCATCTGGTGACTCGAAATGAAGCTGACTTTAGAGAAGCGGGTATTATCG
TCGTCAATCCCTGGAACCAGTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT167574 WP_001223208.1 NZ_CP058826:c3922618-3922367 [Shigella flexneri]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT167574 NZ_CP075171:4093511-4093765 [Leptodesmis sichuanensis PKUAC-SCTA121]
ATGTCTGAAGTGTGGCAATTACAAACTGCAAAAAATAAATTTAGTGAAGTTGTGGAGCAAGCGATTCAGCATGGCCCGCA
AGTGATTACTCGGCGGGGGAATGAAGTTGCTGTGGTGTTGTCCTATGCCGATTACCGCAAACTGACAACTCCTCAGACCA
AGCTCTCGGTCTTTTTCAGAGAATCGCCATTAGCCAAAGTTGAACTGGATCTTACCCGTGATGTCAGTGCTGCCAGGGAT
GACCTGATGCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References