Detailed information of TA system TA167570

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 3467705..3468503
• Replicon: chromosome
• Accession: NZ_CP058826
• Organism: Shigella flexneri strain STLE1

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: A0A166U9J9
• Locus tag: HZT18_RS16920
• Protein ID: WP_000854695.1
• Coordinates: 3467705..3468082 (-)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: A0A2U2UUE3
• Locus tag: HZT18_RS16925
• Protein ID: WP_016243360.1
• Coordinates: 3468129..3468503 (-)
• Length: 125 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HZT18_RS16885	3462720..3463008	-	289	Protein_3316	PerC family transcriptional regulator	-
HZT18_RS16890	3463005..3463535	-	531	WP_001723124.1	ProQ/FinO family protein	-
HZT18_RS16895	3463917..3465008	-	1092	Protein_3318	primase-like DNA-binding domain-containing protein	-
HZT18_RS16905	3466273..3466926	-	654	Protein_3320	DUF4942 domain-containing protein	-
HZT18_RS16910	3467011..3467208	-	198	WP_000839228.1	DUF957 domain-containing protein	-
HZT18_RS16915	3467220..3467708	-	489	WP_000761710.1	DUF5983 family protein	-
HZT18_RS16920	3467705..3468082	-	378	WP_000854695.1	TA system toxin CbtA family protein	Toxin
HZT18_RS16925	3468129..3468503	-	375	WP_016243360.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
HZT18_RS16930	3468666..3468887	-	222	WP_000692307.1	DUF987 domain-containing protein	-
HZT18_RS16935	3468956..3469432	-	477	WP_001186773.1	RadC family protein	-
HZT18_RS16940	3469448..3469927	-	480	WP_000860084.1	antirestriction protein	-
HZT18_RS16945	3470009..3470827	-	819	WP_001241366.1	DUF932 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fdeC / ykgK/ecpR / yagZ/ecpA / yagY/ecpB / yagX/ecpC / yagW/ecpD / yagV/ecpE	3434237..3469927	35690

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14062.03 Da
• Isoelectric Point: 7.7531

>T167570 WP_000854695.1 NZ_CP058826:c3468082-3467705 [Shigella flexneri]
MKTLPDTHVREASCCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITRGKHPGAKQ

Nucleotide

• Length: 378 bp

>T167570 NZ_CP075171:c585636-585238 [Leptodesmis sichuanensis PKUAC-SCTA121]
GTGAAACTGTTATTGGATACCCAATGTTGGTTATGGTGGTTTGCTCAACCGGATTGCTTGAATGAGGAGGCAATTTCTCA
CATAGCCGACGAAACCAATGAGCTATGGCTTTCAGTCGCCAGCATTTGGGAAATGGGAATCAAAGTTTCAATTGGGAAGT
TGCCGCTACCCGATCCCATCGATAGCTACGTTCCCAGGCGAATGGCTCAATTAGGGACAAGACCTTTGGAGATTAAAGCA
TCCCACGCGATACAAATAGCCTCATTGCCTCTGCATCATCGCGATCCCTTCGATCGCATATTGATCTCCCAGGCCCAGTT
GGAAAAATTAACCCTGGTCACAGCCGATGCAATTTTTCACCAGTATGATGTTGCTATTCTGTGGGCTGCCAACAGTTAA

Antitoxin

Protein

• Length: 125 a.a.
• Molecular weight: 13810.66 Da
• Isoelectric Point: 7.0266

>AT167570 WP_016243360.1 NZ_CP058826:c3468503-3468129 [Shigella flexneri]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAPATTS

Nucleotide

• Length: 375 bp

>AT167570 NZ_CP075171:c585878-585633 [Leptodesmis sichuanensis PKUAC-SCTA121]
ATGGAAACCGTCAATATTCATCAAGCTAAAAGCAATCTGTCCCGGCTTCTGTCCCGTGTGGAGATGGGTGAGGAGATTAT
TATTTCTAATCGGGGTATTCCAGTCGCCAAGTTGGTTCCCTTCCGTCCGACTACTCATCGACGGGATAGTTTGGGCTGTG
ATCGAGATCGCTTCACGGTGCCGGACAACTTTAATGATCCCTTGCCAGAAGACATTCTGGCCGCATTTGAGGGACAGCAA
TCGTGA

Structures

Toxin

• AlphaFold DB: A0A166U9J9

Antitoxin

• AlphaFold DB: A0A2U2UUE3