Detailed information of TA system TA167567

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2342808..2344396
• Replicon: chromosome
• Accession: NZ_CP058826
• Organism: Shigella flexneri strain STLE1

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: HZT18_RS11425
• Protein ID: WP_172698660.1
• Coordinates: 2343074..2344396 (+)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: HZT18_RS11420
• Protein ID: WP_001301023.1
• Coordinates: 2342808..2343074 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HZT18_RS11420 (2342808)	2342808..2343074	+	267	WP_001301023.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
HZT18_RS11425 (2343074)	2343074..2344396	+	1323	WP_172698660.1	type II toxin-antitoxin system serine/threonine protein kinase toxin HipA	Toxin
HZT18_RS11430 (2344647)	2344647..2346047	+	1401	WP_001409388.1	site-specific integrase	-
HZT18_RS11435 (2346031)	2346031..2346915	+	885	WP_240764628.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-69)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49289.84 Da
• Isoelectric Point: 8.2482

>T167567 WP_172698660.1 NZ_CP058826:2343074-2344396 [Shigella flexneri]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVTHPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NAERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQIFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVESNVLRLHGRLSREYGSK

Nucleotide

• Length: 1323 bp

>T167567 NZ_CP075169:c6438820-6438527 [Sodalis ligni]
ATGCCACAAGTAATCATCACACAACAAGCTGCAACCGGGTTAACGCACAGCCGGGAGTTTCTGACCAGCAAAAATCCGCT
GGCGGCCATCAGGGCGGGTCAGATGCTCGAAGCGCATTTTGAGCAACGGGGAAACAACCCCGAAATGGGCCGCCCTTTTA
CTGAGCTGCCTGTACTGCGGGAACTGAAGATTGAATTCGGCGATTCCGGCTATGTGGCCTTGTACCGCTACGAGAAAATA
GAAGACCGTGTTTATGTGCTGGCCTTTCGGCATCAGAAAGAAGCGGGATATTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10016.38 Da
• Isoelectric Point: 6.2267

>AT167567 WP_001301023.1 NZ_CP058826:2342808-2343074 [Shigella flexneri]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDAKNASPES
TEQQNLEW

Nucleotide

• Length: 267 bp

>AT167567 NZ_CP075169:c6439089-6438808 [Sodalis ligni]
ATGTCAACATCAAGCACCACACTCAAGATCGACGACAGGCTCAAAGCGCGTGTCAAAAAACTGGCGGATTCACGCGATCG
CAGCCCACACTATCTGATGATAGCCGCTATCACTCAATATATTGAACACGAAGAGGCACGCGAGAGTTTTAAACAGGAAG
CCATCGACTCCTGGCGTGAGTATCAGGAAACCGGTCTGCATCTGACCGGTGATGAAGTTAAAACCTGGCTGCGTGGCTGG
GGAACAGAAGTGGAAACGGATATTCCTGAATGCCACAAGTAA