Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 30640..31162 Replicon plasmid unnamed1
Accession NZ_CP058797
Organism Shigella flexneri strain STLIN_8

Toxin (Protein)


Gene name relE Uniprot ID G3CAN5
Locus tag HZT12_RS23640 Protein ID WP_000220560.1
Coordinates 30881..31162 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G3CAG1
Locus tag HZT12_RS23635 Protein ID WP_000121743.1
Coordinates 30640..30891 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZT12_RS23605 (HZT12_23405) 26003..26233 + 231 WP_000051064.1 plasmid partition protein ParG -
HZT12_RS23610 (HZT12_23410) 26249..26542 + 294 WP_015060510.1 hypothetical protein -
HZT12_RS23615 (HZT12_23415) 26544..27512 + 969 WP_000654804.1 IS5-like element IS903B family transposase -
HZT12_RS23620 (HZT12_23420) 27572..27925 - 354 WP_000876434.1 DNA distortion polypeptide 3 -
HZT12_RS23625 (HZT12_23425) 28062..28508 - 447 WP_097728302.1 hypothetical protein -
HZT12_RS23630 (HZT12_23430) 28548..29384 - 837 WP_001050931.1 RepB family plasmid replication initiator protein -
HZT12_RS23635 (HZT12_23435) 30640..30891 + 252 WP_000121743.1 plasmid stabilization protein Antitoxin
HZT12_RS23640 (HZT12_23440) 30881..31162 + 282 WP_000220560.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HZT12_RS23645 (HZT12_23445) 31308..31631 + 324 WP_001181903.1 hypothetical protein -
HZT12_RS23650 (HZT12_23450) 31676..31921 + 246 WP_000356546.1 hypothetical protein -
HZT12_RS23655 (HZT12_23455) 31911..32126 + 216 WP_001180116.1 hypothetical protein -
HZT12_RS23660 (HZT12_23460) 32219..32548 + 330 WP_000866648.1 hypothetical protein -
HZT12_RS23665 (HZT12_23465) 32835..32984 + 150 WP_000003880.1 hypothetical protein -
HZT12_RS23670 (HZT12_23470) 32997..33269 + 273 WP_000160399.1 hypothetical protein -
HZT12_RS23675 (HZT12_23475) 33596..34141 + 546 WP_038976855.1 DNA distortion polypeptide 1 -
HZT12_RS23680 (HZT12_23480) 34144..35301 + 1158 WP_000538023.1 DNA distortion polypeptide 2 -
HZT12_RS23685 (HZT12_23485) 35662..36153 + 492 WP_000872475.1 transcription termination/antitermination NusG family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid qnrS1 / dfrA5 / floR / tet(A) / blaTEM-176 / aph(3')-Ia - 1..53820 53820


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11005.83 Da        Isoelectric Point: 10.5938

>T167552 WP_000220560.1 NZ_CP058797:30881-31162 [Shigella flexneri]
MTYELAFDRRALKEWQKLGHTIREQFKKKLAERLENPRVPAARLHGHADRYKIKLRASGYRLVYQVIDEKVVLLVIAVGR
RESSEVYQIADLR

Download         Length: 282 bp

>T167552 NZ_CP075169:992507-992782 [Sodalis ligni]
ATGCGACAGAAAATTACCGGCCTACGTAAGAAGCAACGGACGGTGTTAAATCAAATTTTCAAAACGCCGGTACCCTCTGG
CGTCAAATGGTCTGATATTGAGTCACTCGTTTGCGCATTAGGGGGTGAAATCAAGGAAGGCAGCGGGTCTCGGGTAAGGC
TTTTACTTAATGGCTGTATTGCCCGGTTTCATCGTCCCCATCCGTCGCCTGAAGCTGACAAGGGGGCGTTAGCCAACTTG
AGGGAATGGCTGGAGAGCATAGGAGTCGAACCATGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9194.43 Da        Isoelectric Point: 4.1683

>AT167552 WP_000121743.1 NZ_CP058797:30640-30891 [Shigella flexneri]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKNPEIVKVNL
DDL

Download         Length: 252 bp

>AT167552 NZ_CP075169:992779-993141 [Sodalis ligni]
ATGAAAAAAGTATTGAAAACCCCTAATACCATGGTTGTTGCCGGACAGCCGGCCATTATCAGCTATGTTCCGGAAATTGG
CATGTTCCGCGGTAAGTTTATCGGCCTATCGGGCTATTGTGACTTTGTTGCCGATAGCATCGACGGTTTGAAAAGCGAAG
GGGAGGTGTCGTTGCGTGAATACCTGGAAGATTGCCGGGAAAATCACATCGACCCTTACGAACGGGAAGAGAAAGTGAAA
ACCTTTACCCTCCGCTACCCTGAATCGTTCGGGGAGCAGTTGGCCGTTGCTGCCGCTGAACATCATGTCTCGGTGAATTC
ATTTATTGTTGAAACGTTAAATGAACGCCTTAAACACGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G3CAN5

Antitoxin

Source ID Structure
AlphaFold DB A0A3S5I301

References