Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 2341425..2341951 | Replicon | chromosome |
| Accession | NZ_CP058796 | ||
| Organism | Shigella flexneri strain STLIN_8 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | HZT12_RS11585 | Protein ID | WP_000323025.1 |
| Coordinates | 2341664..2341951 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | HZT12_RS11580 | Protein ID | WP_000534858.1 |
| Coordinates | 2341425..2341664 (+) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HZT12_RS11550 (2336465) | 2336465..2336886 | + | 422 | Protein_2264 | hypothetical protein | - |
| HZT12_RS11555 (2337521) | 2337521..2338862 | + | 1342 | Protein_2265 | ISNCY family transposase | - |
| HZT12_RS11560 (2339299) | 2339299..2339511 | - | 213 | Protein_2266 | FlxA-like family protein | - |
| HZT12_RS11565 (2339575) | 2339575..2340737 | + | 1163 | WP_085947771.1 | IS3-like element IS3 family transposase | - |
| HZT12_RS11570 (2340767) | 2340767..2340892 | - | 126 | Protein_2268 | protein FlxA | - |
| HZT12_RS11575 (2341095) | 2341095..2341400 | - | 306 | WP_001326990.1 | protein YdfV | - |
| HZT12_RS11580 (2341425) | 2341425..2341664 | + | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| HZT12_RS11585 (2341664) | 2341664..2341951 | + | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| HZT12_RS11590 (2342023) | 2342023..2342178 | + | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| HZT12_RS11595 (2342395) | 2342395..2342646 | + | 252 | WP_000980994.1 | protein Rem | - |
| HZT12_RS11600 (2342713) | 2342713..2342991 | + | 279 | WP_012304870.1 | hypothetical protein | - |
| HZT12_RS11605 (2342993) | 2342993..2344042 | + | 1050 | WP_001265198.1 | DUF968 domain-containing protein | - |
| HZT12_RS11610 (2344056) | 2344056..2344808 | + | 753 | WP_001047135.1 | antitermination protein | - |
| HZT12_RS11615 (2345086) | 2345086..2345175 | - | 90 | WP_120795389.1 | hypothetical protein | - |
| HZT12_RS11620 (2345230) | 2345230..2345442 | - | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| HZT12_RS11625 (2345743) | 2345743..2345958 | + | 216 | WP_000066484.1 | cold shock-like protein CspB | - |
| HZT12_RS11630 (2346322) | 2346322..2346492 | - | 171 | WP_213044735.1 | YnfU family zinc-binding protein | - |
| HZT12_RS11635 (2346712) | 2346712..2346927 | + | 216 | WP_000839590.1 | phage lysis protein EssD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2332048..2359961 | 27913 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T167543 WP_000323025.1 NZ_CP058796:2341664-2341951 [Shigella flexneri]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T167543 NZ_CP075141:c4658580-4658269 [Salmonella enterica]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGATGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGATGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT167543 WP_000534858.1 NZ_CP058796:2341425-2341664 [Shigella flexneri]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT167543 NZ_CP075141:c4658268-4657978 [Salmonella enterica]
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAACCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAGC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAACCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAGC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|