Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 110433..110955 Replicon plasmid unnamed1
Accession NZ_CP058791
Organism Shigella flexneri strain STLIN_6

Toxin (Protein)


Gene name relE Uniprot ID G3CAN5
Locus tag HZT08_RS24025 Protein ID WP_000220560.1
Coordinates 110674..110955 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G3CAG1
Locus tag HZT08_RS24020 Protein ID WP_000121743.1
Coordinates 110433..110684 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZT08_RS24000 (106758) 106758..107387 + 630 WP_240766704.1 hypothetical protein -
HZT08_RS24005 (107384) 107384..107740 - 357 WP_000456533.1 DNA distortion polypeptide 3 -
HZT08_RS24010 (107877) 107877..108323 - 447 WP_000057426.1 hypothetical protein -
HZT08_RS24015 (108363) 108363..109199 - 837 WP_001050931.1 RepB family plasmid replication initiator protein -
HZT08_RS24020 (110433) 110433..110684 + 252 WP_000121743.1 plasmid stabilization protein Antitoxin
HZT08_RS24025 (110674) 110674..110955 + 282 WP_000220560.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HZT08_RS24030 (111101) 111101..111424 + 324 WP_001181907.1 hypothetical protein -
HZT08_RS24035 (111469) 111469..111714 + 246 WP_000356545.1 hypothetical protein -
HZT08_RS24040 (111704) 111704..111919 + 216 WP_001180116.1 hypothetical protein -
HZT08_RS24045 (112308) 112308..113495 - 1188 WP_000937591.1 IS91 family transposase -
HZT08_RS24050 (113495) 113495..113860 - 366 WP_000091308.1 hypothetical protein -
HZT08_RS24055 (114137) 114137..114697 - 561 Protein_136 transposase -
HZT08_RS24060 (115288) 115288..115629 - 342 Protein_137 IS3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - estIa / paa / hlyD / hlyB / hlyA / hlyC 1..137079 137079


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11005.83 Da        Isoelectric Point: 10.5938

>T167528 WP_000220560.1 NZ_CP058791:110674-110955 [Shigella flexneri]
MTYELAFDRRALKEWQKLGHTIREQFKKKLAERLENPRVPAARLHGHADRYKIKLRASGYRLVYQVIDEKVVLLVIAVGR
RESSEVYQIADLR

Download         Length: 282 bp

>T167528 NZ_CP075140:4581450-4581932 [Salmonella enterica]
ATGGAAATAAATGTTACTGCACCTGAGCTGCTGAACGAGGAGCATATTCTCCAATCTTTCGATTGCGGGAATGATGTATT
AAGCGACTGGCTTTGCCGCCGCGCTATGAAGAATCAGCACCTCAATGCATCCCGTACATTTGTGATCTGCCTTGAATGCA
CAAAACGCGTAGTAGGATATTATTCTATTGCGACGGGATCTATAAGCCATGTCGATTTAGGTCGCAGCCTGCGTCAGAAT
ATGCCCGATCCTGTTCCAGTTGTTTTATTGGGACGTCTTGCTATTGATAAGTGTACTCAGGGTCAAAATTTCGGTAAATG
GCTGCTTAATGATGCTGTAACGCGAGTATCAAACCTGGCAGATCAGGTGGGGATTAAAGCGATCATGGTGCATGCTATTG
ATGAACAAGCGAAAGCATTCTATGAATATTTTGGCTTCGTTCAGTCCCCCGTTGCACCAAACACATTGTTCTACAAGATT
TAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9194.43 Da        Isoelectric Point: 4.1683

>AT167528 WP_000121743.1 NZ_CP058791:110433-110684 [Shigella flexneri]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKNPEIVKVNL
DDL

Download         Length: 252 bp

>AT167528 NZ_CP075140:4581175-4581459 [Salmonella enterica]
ATGCAAACTACAACCCGTAAATCTATTCGTAATAAACAAATAAATATTCGAGCGACTGATGAGGAGCGCGCAGTAATTGA
CTATGCAGCAAAGTTGGTCAGTAAAAATCGCACTGATTTCATCATAGAGAAAGCTGTGAATGAAGCTCAGAATATCATTC
TGGATCAGCGAGTTTTCGTTCTGGATGATGCTCGTTACCAGGCATTCATTGAACAGCTCGAAGCCCCAGTTCAGAATGTT
GAGGGTCGTCAGCGGCTGATGGATGTAAAACCTGAATGGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G3CAN5

Antitoxin

Source ID Structure
AlphaFold DB A0A3S5I301

References