Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) KacT-ataR/ElaA-DUF1778
Location 27310..28113 Replicon plasmid unnamed1
Accession NZ_CP058791
Organism Shigella flexneri strain STLIN_6

Toxin (Protein)


Gene name KacT Uniprot ID -
Locus tag HZT08_RS23540 Protein ID WP_000348879.1
Coordinates 27583..28113 (+) Length 177 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID -
Locus tag HZT08_RS23535 Protein ID WP_000114669.1
Coordinates 27310..27579 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZT08_RS23510 (23729) 23729..24415 + 687 WP_001031857.1 fimbrial chaperone -
HZT08_RS23515 (24415) 24415..25416 + 1002 WP_240766714.1 protein fanF -
HZT08_RS23520 (25416) 25416..25940 + 525 WP_000737845.1 spore coat protein U domain-containing protein -
HZT08_RS23525 (25933) 25933..26460 + 528 WP_000592915.1 hypothetical protein -
HZT08_RS23530 (26621) 26621..27117 + 497 Protein_32 tyrosine-type recombinase/integrase -
HZT08_RS23535 (27310) 27310..27579 + 270 WP_000114669.1 DUF1778 domain-containing protein Antitoxin
HZT08_RS23540 (27583) 27583..28113 + 531 WP_000348879.1 GNAT family N-acetyltransferase Toxin
HZT08_RS23545 (28595) 28595..29292 + 698 WP_103215986.1 IS1-like element IS1A family transposase -
HZT08_RS23550 (29396) 29396..29614 - 219 WP_001353651.1 heat-stable enterotoxin ST-I group a -
HZT08_RS23560 (31002) 31002..31322 - 321 Protein_38 Tn3 family transposase -
HZT08_RS23565 (31536) 31536..32294 + 759 WP_001257942.1 substrate-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - estIa / paa / hlyD / hlyB / hlyA / hlyC 1..137079 137079


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(92-156)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 177 a.a.        Molecular weight: 20402.29 Da        Isoelectric Point: 6.6389

>T167517 WP_000348879.1 NZ_CP058791:27583-28113 [Shigella flexneri]
MDGLRIEIFSEEVEYELSNFDCGEEYLNTFLTDHLKRQHNSKILRGYLLVTREDKPRVMGYYTLSGSCFEKTLLPSKTQQ
KRVPYKNVPSVTLGRLAIDKNLHRQGYGETLVTHAMKVVYQASQAVGIHGMFVEALNDNAKKFYLRMGFIQLKEENCNSL
FYPTKSIEELFEVNDE

Download         Length: 531 bp

>T167517 NZ_CP075140:471493-471768 [Salmonella enterica]
ATGAAACAGGTATTAAAAGATTTTGACGTCGCAGACTATTTAGAGGACGAGGATGATGTTATCGCTTATCTAAATGCCGT
TATTGCCGAGGGTGACAATAAACAACTTTTCATTGCGCTGGGCAACATTGCAAGAGCAAGAAATATAAGCCGTATTTCAA
AAGAAACCGGAATCAGCAGGGAGGGAATTTATAAAGCACTTTCAGGCGATGGAAATCCATCATTTAACACCCTTTCTAAA
ATAACTAAAGCGATGGGGTTAGATCTTCACTTTTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10341.85 Da        Isoelectric Point: 6.4742

>AT167517 WP_000114669.1 NZ_CP058791:27310-27579 [Shigella flexneri]
MSVLKKQRIDLRLNEDDKHMIEEAAAMTNQSISQFMVSTASERAAEVIDQHRRLLLNEESWNLVMDAITNPPVPNERLKR
AAKRLRELE

Download         Length: 270 bp

>AT167517 NZ_CP075140:471195-471491 [Salmonella enterica]
ATGATTGACATAAAAACAACACCAGAGGCCGAGAAGTGGCTAAAGGGATTGAAAGACCGGGTAGCGAAATCAAAGATATT
AATCAGAATCGACAGAATGAGAACGGGGAACTTTGGTGATGTTGAGCCAGTAGGCGGCGGGTTATCTGAATTGCGCATAC
ATCACGGCAAAGGTTATCGGGTTTATTTTGGGAATAAAAACAACGAAATAATATTAATTCTTTGTGGCGGGGATAAAAGC
ACACAGCAGGATGATATACAGAAAGCGAAACAGATAGCCAAAAAATGGGGGTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References