Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mosAT/AbiEii-AbiEi |
| Location | 4083229..4084951 | Replicon | chromosome |
| Accession | NZ_CP058790 | ||
| Organism | Shigella flexneri strain STLIN_6 | ||
Toxin (Protein)
| Gene name | mosT | Uniprot ID | A0A229ALQ0 |
| Locus tag | HZT08_RS19850 | Protein ID | WP_052921265.1 |
| Coordinates | 4083229..4084167 (-) | Length | 313 a.a. |
Antitoxin (Protein)
| Gene name | mosA | Uniprot ID | A0A229AKX4 |
| Locus tag | HZT08_RS19855 | Protein ID | WP_052921266.1 |
| Coordinates | 4084160..4084951 (-) | Length | 264 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HZT08_RS19830 (4078543) | 4078543..4080942 | - | 2400 | WP_052921263.1 | type IV secretion system protein TraC | - |
| HZT08_RS19835 (4080942) | 4080942..4081634 | - | 693 | WP_024008832.1 | DsbC family protein | - |
| HZT08_RS19840 (4081876) | 4081876..4082022 | + | 147 | WP_162869655.1 | hypothetical protein | - |
| HZT08_RS19845 (4082066) | 4082066..4082722 | + | 657 | WP_052921264.1 | hypothetical protein | - |
| HZT08_RS19850 (4083229) | 4083229..4084167 | - | 939 | WP_052921265.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
| HZT08_RS19855 (4084160) | 4084160..4084951 | - | 792 | WP_052921266.1 | type IV toxin-antitoxin system AbiEi family antitoxin | Antitoxin |
| HZT08_RS19860 (4085171) | 4085171..4085557 | - | 387 | WP_000180225.1 | TraA family conjugative transfer protein | - |
| HZT08_RS19865 (4085554) | 4085554..4086126 | - | 573 | WP_024008834.1 | type IV conjugative transfer system lipoprotein TraV | - |
| HZT08_RS19870 (4086201) | 4086201..4087490 | - | 1290 | WP_052921268.1 | TraB/VirB10 family protein | - |
| HZT08_RS19875 (4087493) | 4087493..4088389 | - | 897 | WP_052921278.1 | type-F conjugative transfer system secretin TraK | - |
| HZT08_RS19880 (4088373) | 4088373..4088999 | - | 627 | WP_000667170.1 | TraE/TraK family type IV conjugative transfer system protein | - |
| HZT08_RS19885 (4088996) | 4088996..4089277 | - | 282 | WP_000433889.1 | type IV conjugative transfer system protein TraL | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | lpxC / espX1 / espX1 | 3898499..4128899 | 230400 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 313 a.a. Molecular weight: 35487.78 Da Isoelectric Point: 5.1093
>T167514 WP_052921265.1 NZ_CP058790:c4084167-4083229 [Shigella flexneri]
MDKGSPYYKQVSLLIRMLPVVATETVFALKGGTAINLFVRDFPRLSVDIDLAYLPLEPRDEALVNVRAALQRITDRINTQ
PDIRAAFQDNKADELRIVVSSLVATIKIEVSPVARGTLHSAEIMPVQESVEDEFGYAEIQVVSLPDLYGGKLCAAMDRQH
PRDLFDVRMLLGSEGISREILVGFLTYTLSHPRPINEVMSPNWQPLNEKFQAEFDGMTFEKVECEDLASVRPMMLTSLQK
HFTERDHAFLMSFKRGQPDWALFDYPNAADLPAIRWKLQNIYKLAKNQAKHQEQLDKLKQVLDDWLVNANAE
MDKGSPYYKQVSLLIRMLPVVATETVFALKGGTAINLFVRDFPRLSVDIDLAYLPLEPRDEALVNVRAALQRITDRINTQ
PDIRAAFQDNKADELRIVVSSLVATIKIEVSPVARGTLHSAEIMPVQESVEDEFGYAEIQVVSLPDLYGGKLCAAMDRQH
PRDLFDVRMLLGSEGISREILVGFLTYTLSHPRPINEVMSPNWQPLNEKFQAEFDGMTFEKVECEDLASVRPMMLTSLQK
HFTERDHAFLMSFKRGQPDWALFDYPNAADLPAIRWKLQNIYKLAKNQAKHQEQLDKLKQVLDDWLVNANAE
Download Length: 939 bp
>T167514 NZ_CP075138:c4684812-4684501 [Salmonella enterica]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGAGGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGAGGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG
Antitoxin
Download Length: 264 a.a. Molecular weight: 30113.48 Da Isoelectric Point: 9.5097
>AT167514 WP_052921266.1 NZ_CP058790:c4084951-4084160 [Shigella flexneri]
MSSKINWLVAHTSPGALVLQQWLTENGVSYSLAQKYAQNGWLKKLSSGVYYRPNAQGDIKPTWVDAIQALDVQLGVSVHL
AGLSSLTHQGLSHYLQLNKEQVWICVKNKSSLPKWFREFPYQNWFYCGNHKLELNPEKDLKRITVKEKELTVSCAELAAY
EVVDGIGKLISFEHVAELFQGLVNLSPRKVQDILERSSSVQANRIFLFLGRYYDHQWINRIDETRIKLGAGKRQVVEKGR
FDERYQITVPEILSVKKGEQHNG
MSSKINWLVAHTSPGALVLQQWLTENGVSYSLAQKYAQNGWLKKLSSGVYYRPNAQGDIKPTWVDAIQALDVQLGVSVHL
AGLSSLTHQGLSHYLQLNKEQVWICVKNKSSLPKWFREFPYQNWFYCGNHKLELNPEKDLKRITVKEKELTVSCAELAAY
EVVDGIGKLISFEHVAELFQGLVNLSPRKVQDILERSSSVQANRIFLFLGRYYDHQWINRIDETRIKLGAGKRQVVEKGR
FDERYQITVPEILSVKKGEQHNG
Download Length: 792 bp
>AT167514 NZ_CP075138:c4684500-4684210 [Salmonella enterica]
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAGCCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAAC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAGCCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAAC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A229ALQ0 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A229AKX4 |