Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 866543..867197 Replicon chromosome
Accession NZ_CP058790
Organism Shigella flexneri strain STLIN_6

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag HZT08_RS04255 Protein ID WP_240766504.1
Coordinates 866790..867197 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag HZT08_RS04250 Protein ID WP_000354046.1
Coordinates 866543..866809 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZT08_RS04225 (861831) 861831..862574 + 744 WP_000951964.1 SDR family oxidoreductase -
HZT08_RS04230 (862631) 862631..864064 - 1434 WP_001387034.1 6-phospho-beta-glucosidase BglA -
HZT08_RS04235 (864109) 864109..864420 + 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
HZT08_RS04240 (864584) 864584..865243 + 660 WP_000250274.1 hemolysin III family protein -
HZT08_RS04245 (865320) 865320..866300 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
HZT08_RS04250 (866543) 866543..866809 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
HZT08_RS04255 (866790) 866790..867197 + 408 WP_240766504.1 protein YgfX Toxin
HZT08_RS04260 (867237) 867237..867758 - 522 WP_001055874.1 flavodoxin FldB -
HZT08_RS04265 (867870) 867870..868766 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
HZT08_RS04270 (868791) 868791..869501 + 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HZT08_RS04275 (869507) 869507..871240 + 1734 WP_000813215.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15978.91 Da        Isoelectric Point: 10.9373

>T167496 WP_240766504.1 NZ_CP058790:866790-867197 [Shigella flexneri]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWCIVKAPWMIKSGMMLRLSSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T167496 NZ_CP075137:2046989-2047092 [Salmonella enterica]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT167496 WP_000354046.1 NZ_CP058790:866543-866809 [Shigella flexneri]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT167496 NZ_CP075137:c2047094-2046949 [Salmonella enterica]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References