Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3490855..3491473 Replicon chromosome
Accession NZ_CP058786
Organism Shigella flexneri strain STLIN_4

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag HZT07_RS17140 Protein ID WP_001291435.1
Coordinates 3491255..3491473 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag HZT07_RS17135 Protein ID WP_000344800.1
Coordinates 3490855..3491229 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZT07_RS17125 (3485944) 3485944..3487137 + 1194 WP_240763433.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HZT07_RS17130 (3487160) 3487160..3490309 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
HZT07_RS17135 (3490855) 3490855..3491229 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
HZT07_RS17140 (3491255) 3491255..3491473 + 219 WP_001291435.1 HHA domain-containing protein Toxin
HZT07_RS17145 (3491645) 3491645..3492196 + 552 WP_000102564.1 maltose O-acetyltransferase -
HZT07_RS17150 (3492312) 3492312..3492782 + 471 WP_000136192.1 YlaC family protein -
HZT07_RS17155 (3492946) 3492946..3494496 + 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
HZT07_RS17160 (3494538) 3494538..3494891 - 354 WP_000878140.1 DUF1428 domain-containing protein -
HZT07_RS17170 (3495270) 3495270..3495581 + 312 WP_000409911.1 MGMT family protein -
HZT07_RS17175 (3495612) 3495612..3496184 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T167484 WP_001291435.1 NZ_CP058786:3491255-3491473 [Shigella flexneri]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T167484 NZ_CP075135:3555286-3555504 [Salmonella enterica]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT167484 WP_000344800.1 NZ_CP058786:3490855-3491229 [Shigella flexneri]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT167484 NZ_CP075135:3554884-3555258 [Salmonella enterica]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCTCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCTAATCCTGTTAGTTTGTCTTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References