Detailed information of TA system TA167483

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/UPF0150(antitoxin)
• Location: 2434743..2435381
• Replicon: chromosome
• Accession: NZ_CP058786
• Organism: Shigella flexneri strain STLIN_4

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A0A6TXU8
• Locus tag: HZT07_RS11940
• Protein ID: WP_001447010.1
• Coordinates: 2435205..2435381 (-)
• Length: 59 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: HZT07_RS11935
• Protein ID: WP_001270286.1
• Coordinates: 2434743..2435159 (-)
• Length: 139 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HZT07_RS11915 (2429895)	2429895..2430836	-	942	WP_001251304.1	ABC transporter permease	-
HZT07_RS11920 (2430837)	2430837..2431850	-	1014	WP_000220396.1	ABC transporter ATP-binding protein	-
HZT07_RS11925 (2431868)	2431868..2433013	-	1146	WP_000047424.1	ABC transporter substrate-binding protein	-
HZT07_RS11930 (2433258)	2433258..2434664	-	1407	WP_000760626.1	PLP-dependent aminotransferase family protein	-
HZT07_RS11935 (2434743)	2434743..2435159	-	417	WP_001270286.1	type II toxin-antitoxin system antitoxin HicB	Antitoxin
HZT07_RS11940 (2435205)	2435205..2435381	-	177	WP_001447010.1	type II toxin-antitoxin system mRNA interferase toxin HicA	Toxin
HZT07_RS11945 (2435603)	2435603..2435833	+	231	WP_000494244.1	YncJ family protein	-
HZT07_RS11950 (2435925)	2435925..2437886	-	1962	WP_001303492.1	23S rRNA 5-hydroxycytidine C2501 synthase	-
HZT07_RS11955 (2437959)	2437959..2438495	-	537	WP_000429155.1	DNA-binding transcriptional regulator SutR	-
HZT07_RS11960 (2438587)	2438587..2439762	+	1176	WP_001236265.1	BenE family transporter YdcO	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (91-134)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6779.86 Da
• Isoelectric Point: 11.2298

>T167483 WP_001447010.1 NZ_CP058786:c2435381-2435205 [Shigella flexneri]
VKQSEFRRWLESQGVDVANSSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Nucleotide

• Length: 177 bp

>T167483 NZ_CP075135:c2205616-2205434 [Salmonella enterica]
ATGAAATATAACGAGTTCAGGCGGTGGCTCATCCAACAGGGTGCAAAGTTCATAAATGCACCGGATGGCGGCAGCCATCA
GCGTGTCATACTGAACGGGAAAGAATCTGTATTTCCCTGCCATGGCGCCAAAGAAATGCCGGAGCCGCTCAGAAAGAAAA
TACTCAAGGATTTGGGGCTTTAA

Antitoxin

Protein

• Length: 139 a.a.
• Molecular weight: 15246.63 Da
• Isoelectric Point: 4.7386

>AT167483 WP_001270286.1 NZ_CP058786:c2435159-2434743 [Shigella flexneri]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Nucleotide

• Length: 417 bp

>AT167483 NZ_CP075135:c2205405-2204971 [Salmonella enterica]
ATGTTTAACTATGCTGTGAAACCTGAGTATGACCCCGCAACAGAAAGCTGGGTTGTCACATGCCGGGATCTGCCACTATT
TAACTCCGTGAGTTTCAGCATTGACGATGCGCTTCTTGAGGCGGTTGATGGTGCCATCGTTGCACTCTCAATCGAAATCG
ACGCACGCCGTCCAGTCCCCATCGCCAGCCAGCCCGAAGAAGGGGAGTATGTCATTCATCTTCCCGTTCTGGTTGTGATG
AAAGCCGCGCTGCATAATGCAATGATTTCCACAGGGACACGAAAATCCGATCTTGCCCGAACTATGGGGATGAAAGGTCC
CCAGATAGATCGCCTCCTGGATGTTTGCCACTCATCGAAAGTGGAAACAGTAGAACTCGCTCTTCAGCAACTCAACCGGA
CTGTACAGATAAGCGTTGATAACGTTGCGGTATAA

Structures

Toxin

• AlphaFold DB: A0A0A6TXU8