Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2434743..2435381 Replicon chromosome
Accession NZ_CP058786
Organism Shigella flexneri strain STLIN_4

Toxin (Protein)


Gene name hicA Uniprot ID A0A0A6TXU8
Locus tag HZT07_RS11940 Protein ID WP_001447010.1
Coordinates 2435205..2435381 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag HZT07_RS11935 Protein ID WP_001270286.1
Coordinates 2434743..2435159 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZT07_RS11915 (2429895) 2429895..2430836 - 942 WP_001251304.1 ABC transporter permease -
HZT07_RS11920 (2430837) 2430837..2431850 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
HZT07_RS11925 (2431868) 2431868..2433013 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
HZT07_RS11930 (2433258) 2433258..2434664 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
HZT07_RS11935 (2434743) 2434743..2435159 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
HZT07_RS11940 (2435205) 2435205..2435381 - 177 WP_001447010.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
HZT07_RS11945 (2435603) 2435603..2435833 + 231 WP_000494244.1 YncJ family protein -
HZT07_RS11950 (2435925) 2435925..2437886 - 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
HZT07_RS11955 (2437959) 2437959..2438495 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
HZT07_RS11960 (2438587) 2438587..2439762 + 1176 WP_001236265.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6779.86 Da        Isoelectric Point: 11.2298

>T167483 WP_001447010.1 NZ_CP058786:c2435381-2435205 [Shigella flexneri]
VKQSEFRRWLESQGVDVANSSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T167483 NZ_CP075135:c2205616-2205434 [Salmonella enterica]
ATGAAATATAACGAGTTCAGGCGGTGGCTCATCCAACAGGGTGCAAAGTTCATAAATGCACCGGATGGCGGCAGCCATCA
GCGTGTCATACTGAACGGGAAAGAATCTGTATTTCCCTGCCATGGCGCCAAAGAAATGCCGGAGCCGCTCAGAAAGAAAA
TACTCAAGGATTTGGGGCTTTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT167483 WP_001270286.1 NZ_CP058786:c2435159-2434743 [Shigella flexneri]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT167483 NZ_CP075135:c2205405-2204971 [Salmonella enterica]
ATGTTTAACTATGCTGTGAAACCTGAGTATGACCCCGCAACAGAAAGCTGGGTTGTCACATGCCGGGATCTGCCACTATT
TAACTCCGTGAGTTTCAGCATTGACGATGCGCTTCTTGAGGCGGTTGATGGTGCCATCGTTGCACTCTCAATCGAAATCG
ACGCACGCCGTCCAGTCCCCATCGCCAGCCAGCCCGAAGAAGGGGAGTATGTCATTCATCTTCCCGTTCTGGTTGTGATG
AAAGCCGCGCTGCATAATGCAATGATTTCCACAGGGACACGAAAATCCGATCTTGCCCGAACTATGGGGATGAAAGGTCC
CCAGATAGATCGCCTCCTGGATGTTTGCCACTCATCGAAAGTGGAAACAGTAGAACTCGCTCTTCAGCAACTCAACCGGA
CTGTACAGATAAGCGTTGATAACGTTGCGGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6TXU8

Antitoxin

Source ID Structure

References