Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 2297159..2297685 | Replicon | chromosome |
| Accession | NZ_CP058786 | ||
| Organism | Shigella flexneri strain STLIN_4 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | HZT07_RS11250 | Protein ID | WP_000323025.1 |
| Coordinates | 2297398..2297685 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | HZT07_RS11245 | Protein ID | WP_000534858.1 |
| Coordinates | 2297159..2297398 (+) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HZT07_RS11215 (2292887) | 2292887..2293117 | - | 231 | Protein_2199 | IS66 family insertion sequence element accessory protein TnpB | - |
| HZT07_RS11220 (2293123) | 2293123..2293245 | - | 123 | Protein_2200 | transposase | - |
| HZT07_RS11225 (2293488) | 2293488..2293909 | + | 422 | Protein_2201 | hypothetical protein | - |
| HZT07_RS11230 (2294544) | 2294544..2295857 | + | 1314 | WP_000589005.1 | ISNCY family transposase | - |
| HZT07_RS11235 (2296294) | 2296294..2296626 | - | 333 | WP_001301033.1 | FlxA-like family protein | - |
| HZT07_RS11240 (2296829) | 2296829..2297134 | - | 306 | WP_001326990.1 | protein YdfV | - |
| HZT07_RS11245 (2297159) | 2297159..2297398 | + | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| HZT07_RS11250 (2297398) | 2297398..2297685 | + | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| HZT07_RS11255 (2297757) | 2297757..2297912 | + | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| HZT07_RS11260 (2298129) | 2298129..2298380 | + | 252 | WP_000980994.1 | protein Rem | - |
| HZT07_RS11265 (2298447) | 2298447..2298725 | + | 279 | WP_012304870.1 | hypothetical protein | - |
| HZT07_RS11270 (2298727) | 2298727..2299776 | + | 1050 | WP_001265199.1 | DUF968 domain-containing protein | - |
| HZT07_RS11275 (2299790) | 2299790..2300542 | + | 753 | WP_001047135.1 | antitermination protein | - |
| HZT07_RS11280 (2300820) | 2300820..2300909 | - | 90 | WP_120795389.1 | hypothetical protein | - |
| HZT07_RS11285 (2300964) | 2300964..2301176 | - | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| HZT07_RS11290 (2301477) | 2301477..2301692 | + | 216 | WP_000066484.1 | cold shock-like protein CspB | - |
| HZT07_RS11295 (2302056) | 2302056..2302226 | - | 171 | WP_211180497.1 | putative zinc-binding protein YnfU | - |
| HZT07_RS11300 (2302446) | 2302446..2302661 | + | 216 | WP_000839590.1 | phage lysis protein EssD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2286244..2319770 | 33526 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T167481 WP_000323025.1 NZ_CP058786:2297398-2297685 [Shigella flexneri]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T167481 NZ_CP075135:949142-949555 [Salmonella enterica]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CGCGCCAACACTGA
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CGCGCCAACACTGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT167481 WP_000534858.1 NZ_CP058786:2297159-2297398 [Shigella flexneri]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT167481 NZ_CP075135:948895-949161 [Salmonella enterica]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGATGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGATGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|