Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 753521..754319 Replicon chromosome
Accession NZ_CP058786
Organism Shigella flexneri strain STLIN_4

Toxin (Protein)


Gene name yeeV Uniprot ID U9XMP3
Locus tag HZT07_RS03690 Protein ID WP_000854735.1
Coordinates 753521..753898 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A1M1EW42
Locus tag HZT07_RS03695 Protein ID WP_032153712.1
Coordinates 753945..754319 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZT07_RS03655 (748563) 748563..749260 + 698 WP_223861965.1 IS1-like element IS1B family transposase -
HZT07_RS03660 (749489) 749489..750751 - 1263 WP_032161224.1 integrase arm-type DNA-binding domain-containing protein -
HZT07_RS03665 (751215) 751215..751541 - 327 WP_000779483.1 type II toxin-antitoxin system RelE/ParE family toxin -
HZT07_RS03670 (751538) 751538..751801 - 264 WP_025492088.1 type II toxin-antitoxin system ParD family antitoxin -
HZT07_RS03675 (751873) 751873..752739 - 867 WP_032153714.1 DUF4942 domain-containing protein -
HZT07_RS03680 (752824) 752824..753021 - 198 WP_000839265.1 DUF957 domain-containing protein -
HZT07_RS03685 (753033) 753033..753524 - 492 WP_023155722.1 DUF5983 family protein -
HZT07_RS03690 (753521) 753521..753898 - 378 WP_000854735.1 TA system toxin CbtA family protein Toxin
HZT07_RS03695 (753945) 753945..754319 - 375 WP_032153712.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
HZT07_RS03700 (754399) 754399..754620 - 222 WP_000692345.1 DUF987 domain-containing protein -
HZT07_RS03705 (754689) 754689..755165 - 477 WP_001186715.1 RadC family protein -
HZT07_RS03710 (755181) 755181..755666 - 486 WP_032153711.1 antirestriction protein -
HZT07_RS03715 (755758) 755758..756576 - 819 WP_001234693.1 DUF932 domain-containing protein -
HZT07_RS03720 (756667) 756667..756876 - 210 WP_023155727.1 DUF905 family protein -
HZT07_RS03725 (756906) 756906..757583 - 678 WP_023155728.1 hypothetical protein -
HZT07_RS03730 (757702) 757702..758586 - 885 WP_024166630.1 50S ribosome-binding GTPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island sul2 / aph(3'')-Ib / aph(6)-Id / tet(A) / floR papI / papB 748596..819472 70876


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14061.07 Da        Isoelectric Point: 8.2904

>T167468 WP_000854735.1 NZ_CP058786:c753898-753521 [Shigella flexneri]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T167468 NZ_CP075134:321598-321966 [Salmonella enterica subsp. enterica serovar Saintpaul]
ATGACCCTACAACTTATCTCAGCGGAAGAGATAATTCAGTTTCACGACAGGCTTCTCCGCGTTACGCCTGGTGTAACAGG
CATGCCTGATCCTGGCCGCGCGGAAGCGCTAATGTACCGGGTACTCAATCAAATCGAATATGAAGGGGTGACCGACGTGT
GGCTGCTGGCGGCAATGCATTTGCTCGCTATATCCCGTGGGCATATCTTCAATGATGGTAACAAACGTACCGCCTTATTT
ATTACGCTGCTGTTTTTAAAGCGTAACGGGATCTCACTCGCTGCGAATCCGGATTTTGTCGATATGACAGTCGATGCGGC
GGCAGGGCGGCTTACGCTGGAGCAAATTGCCGTTCGCTTACGTGCCTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13697.51 Da        Isoelectric Point: 6.6240

>AT167468 WP_032153712.1 NZ_CP058786:c754319-753945 [Shigella flexneri]
VSDTLPGTTHPDDNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT167468 NZ_CP075134:321380-321601 [Salmonella enterica subsp. enterica serovar Saintpaul]
ATGCGTACGGTTAACTATAGCGAAGCGCGGCAAAATCTGGCCGAAGTCCTGGAAAGCGCGGTGACGGCGGGCCCTGTCAC
CATCACGCGTCGTGGGCATAAGTCCGCAGTGATCATCAGCGCCGAGGAGTTTGAGCGTTATCAGACGGCGCGAATGGATG
ATGAGTTTGCTGCCATTATGGCGGTTCATGGCAATGAGCTCAGGGAGTTGGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XMP3

Antitoxin

Source ID Structure
AlphaFold DB A0A1M1EW42

References