Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3399559..3400177 Replicon chromosome
Accession NZ_CP058780
Organism Shigella flexneri strain STLIN_17

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag HZT03_RS16465 Protein ID WP_001291435.1
Coordinates 3399959..3400177 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag HZT03_RS16460 Protein ID WP_000344800.1
Coordinates 3399559..3399933 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZT03_RS16450 (3394648) 3394648..3395841 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HZT03_RS16455 (3395864) 3395864..3399013 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
HZT03_RS16460 (3399559) 3399559..3399933 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
HZT03_RS16465 (3399959) 3399959..3400177 + 219 WP_001291435.1 HHA domain-containing protein Toxin
HZT03_RS16470 (3400349) 3400349..3400900 + 552 WP_000102564.1 maltose O-acetyltransferase -
HZT03_RS16475 (3401016) 3401016..3401486 + 471 WP_000136192.1 YlaC family protein -
HZT03_RS16480 (3401650) 3401650..3403200 + 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
HZT03_RS16485 (3403242) 3403242..3403595 - 354 WP_094337314.1 DUF1428 family protein -
HZT03_RS16495 (3403974) 3403974..3404285 + 312 WP_000409911.1 MGMT family protein -
HZT03_RS16500 (3404316) 3404316..3404888 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T167459 WP_001291435.1 NZ_CP058780:3399959-3400177 [Shigella flexneri]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T167459 NZ_CP075132:1995492-1995722 [Salmonella enterica subsp. enterica serovar Inverness]
ATGAAGGTGTATGGCAGCAATCTCGGAGAACCTCACACCAGCGCCTTTGGTGATGGGCTTTTTGAGCTTCGGATTAAAGG
CAGCGATGGCATCGCTCGCGTTTTTTACTGCACTCTGGCAGGGAAGCGCATCGTCATGCTGCACAGCTTTATAAAGAAGA
CTCAGAAAACCCCTGTAGCTGAACGCAAAAAGGCAGAAACCAGAATGAAGGAGGTTAAGCATGACTGGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT167459 WP_000344800.1 NZ_CP058780:3399559-3399933 [Shigella flexneri]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT167459 NZ_CP075132:1995712-1996020 [Salmonella enterica subsp. enterica serovar Inverness]
ATGACTGGTAAACGTAATGCGCCAACTATAACGCACGATGAAATGGCCGCTAAATGGATGGAAGACCCAGCGTTCAAAGC
TGAATATGACGCCATTGCTGATGAGTTCGCGTTGCTTGACGAAATGCTGGCCGCACGTAAAGAAGCAGGTCTCACCCAGG
CTGAAGTTGCTGAACGGATGGGAACAAAAGCCACTGCTATAACCAGAATGGAAAGCAACCTTGCTGCTGGCGTCAGCGGA
CCATCTTTTACTACGCTGAAAAAGTTCGCACAGGCAACCGGGAAAAAACTACAGATCCGCTTCGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References