Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 3025386..3026091 Replicon chromosome
Accession NZ_CP058780
Organism Shigella flexneri strain STLIN_17

Toxin (Protein)


Gene name relE Uniprot ID S1F406
Locus tag HZT03_RS14655 Protein ID WP_000539521.1
Coordinates 3025386..3025772 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag HZT03_RS14660 Protein ID WP_001280945.1
Coordinates 3025762..3026091 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZT03_RS14635 (3021390) 3021390..3022016 + 627 WP_094337114.1 glutathione S-transferase GstB -
HZT03_RS14640 (3022013) 3022013..3023128 - 1116 WP_000555031.1 aldose sugar dehydrogenase YliI -
HZT03_RS14645 (3023239) 3023239..3023622 - 384 WP_000497137.1 biofilm formation regulator BssR -
HZT03_RS14650 (3023835) 3023835..3025160 + 1326 WP_000049367.1 30S ribosomal protein S12 methylthiotransferase RimO -
HZT03_RS14655 (3025386) 3025386..3025772 + 387 WP_000539521.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HZT03_RS14660 (3025762) 3025762..3026091 + 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
HZT03_RS14665 (3026161) 3026161..3027417 - 1257 Protein_2884 diguanylate cyclase -
HZT03_RS14675 (3028385) 3028385..3029296 - 912 WP_094337227.1 glutathione ABC transporter permease GsiD -
HZT03_RS14680 (3029299) 3029299..3030219 - 921 WP_000936043.1 glutathione ABC transporter permease GsiC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14293.45 Da        Isoelectric Point: 9.9296

>T167458 WP_000539521.1 NZ_CP058780:3025386-3025772 [Shigella flexneri]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

>T167458 NZ_CP075132:1082109-1082212 [Salmonella enterica subsp. enterica serovar Inverness]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT167458 WP_001280945.1 NZ_CP058780:3025762-3026091 [Shigella flexneri]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp

>AT167458 NZ_CP075132:c1082214-1082071 [Salmonella enterica subsp. enterica serovar Inverness]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GCT6

Antitoxin

Source ID Structure

References