Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2405831..2406469 Replicon chromosome
Accession NZ_CP058780
Organism Shigella flexneri strain STLIN_17

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag HZT03_RS11580 Protein ID WP_000813794.1
Coordinates 2406293..2406469 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag HZT03_RS11575 Protein ID WP_001270286.1
Coordinates 2405831..2406247 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZT03_RS11555 (2400983) 2400983..2401924 - 942 WP_001251313.1 ABC transporter permease -
HZT03_RS11560 (2401925) 2401925..2402938 - 1014 WP_000220399.1 ABC transporter ATP-binding protein -
HZT03_RS11565 (2402956) 2402956..2404101 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
HZT03_RS11570 (2404346) 2404346..2405752 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
HZT03_RS11575 (2405831) 2405831..2406247 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
HZT03_RS11580 (2406293) 2406293..2406469 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
HZT03_RS11585 (2406691) 2406691..2406921 + 231 WP_000494244.1 YncJ family protein -
HZT03_RS11590 (2407013) 2407013..2408974 - 1962 WP_001301045.1 23S rRNA 5-hydroxycytidine C2501 synthase -
HZT03_RS11595 (2409047) 2409047..2409583 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
HZT03_RS11600 (2409675) 2409675..2410850 + 1176 WP_001236265.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T167457 WP_000813794.1 NZ_CP058780:c2406469-2406293 [Shigella flexneri]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T167457 NZ_CP075132:360564-360839 [Salmonella enterica subsp. enterica serovar Inverness]
ATGGGGCAAAGGGAAATTGAATATTCGGGACAGTTCCAGAAAGATGTAAAACGGGCACAAAAGCGTCATAAGGATGTCGG
CAAACTTAAAACACTTATGACGCTTCTGATTCACCACCCTTTTCCCCTTCCTGCCATTTATAAAGATCACCCGTTACAAG
GTTCATATAGCGGATACCGGGATGCCCATATTGGGCCTGACTGGATTCTTATTGATAAGATAACGGATGAATGCCTGCGA
TTTGAACGAACAGGAACGCATGCCGATTTATTTTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT167457 WP_001270286.1 NZ_CP058780:c2406247-2405831 [Shigella flexneri]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT167457 NZ_CP075132:360301-360561 [Salmonella enterica subsp. enterica serovar Inverness]
ATGGCTGCAAATGCGCTTGTTCGTGCCCGTATCGACGAAACGCTGAAGAATCAGGCGGCAGATGTCCTGGCTGAAATGGG
GTTAACCATTTCTGATTTGATACGGATTACACTGACTAAAGTTGCGCGTGAAAAGGCATTGCCTTTTGATTTGCGGATAC
CCAATGAGTTAACGTCCCGAACGATAGAAAATAGCGAAGCTGGCGTTGACATTCATAAAGCCAAAGATGCTGATGATTTG
TTTGACCAGTTAGGGATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References