Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 662511..663346 Replicon chromosome
Accession NZ_CP058780
Organism Shigella flexneri strain STLIN_17

Toxin (Protein)


Gene name yeeV Uniprot ID A0A4V2J0G6
Locus tag HZT03_RS03235 Protein ID WP_061360226.1
Coordinates 662969..663346 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A7L7B777
Locus tag HZT03_RS03230 Protein ID WP_020218963.1
Coordinates 662511..662879 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZT03_RS03205 (659626) 659626..660444 + 819 WP_001234380.1 DUF932 domain-containing protein -
HZT03_RS03210 (660536) 660536..661021 + 486 WP_000214404.1 antirestriction protein -
HZT03_RS03215 (661036) 661036..661512 + 477 WP_021567035.1 RadC family protein -
HZT03_RS03220 (661581) 661581..661802 + 222 WP_000692312.1 DUF987 domain-containing protein -
HZT03_RS03225 (661817) 661817..662461 + 645 WP_020218962.1 hypothetical protein -
HZT03_RS03230 (662511) 662511..662879 + 369 WP_020218963.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HZT03_RS03235 (662969) 662969..663346 + 378 WP_061360226.1 TA system toxin CbtA family protein Toxin
HZT03_RS03240 (663343) 663343..663831 + 489 WP_000761678.1 DUF5983 family protein -
HZT03_RS03245 (663843) 663843..664040 + 198 WP_000839239.1 DUF957 domain-containing protein -
HZT03_RS03250 (664125) 664125..664991 + 867 WP_061352303.1 DUF4942 domain-containing protein -
HZT03_RS03255 (665063) 665063..665326 + 264 WP_061352304.1 type II toxin-antitoxin system ParD family antitoxin -
HZT03_RS03260 (665323) 665323..665649 + 327 WP_021537629.1 type II toxin-antitoxin system RelE/ParE family toxin -
HZT03_RS03265 (666114) 666114..666581 + 468 Protein_641 Arm DNA-binding domain-containing protein -
HZT03_RS03270 (666646) 666646..667626 + 981 WP_032430896.1 IS5-like element IS5 family transposase -
HZT03_RS03275 (667736) 667736..668029 - 294 WP_095186758.1 LuxR C-terminal-related transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 666646..667626 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14013.95 Da        Isoelectric Point: 7.9086

>T167444 WP_061360226.1 NZ_CP058780:662969-663346 [Shigella flexneri]
MKTLPVLPGQAAGSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
NACTHSQLINSIDILRARRATGLMTRDNYRTVNNITRGKHSEAKQ

Download         Length: 378 bp

>T167444 NZ_CP075129:202141-202626 [Salmonella enterica subsp. enterica serovar Rubislaw]
GTGGGACGTGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTAGCTGAGTTCGTCAGCGGTGAAGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTGCAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGTAGCGTCAACCATACAGAAGCGACAGGCAACCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCATTCCATGGAAAAGGGCTTGGTGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTACCG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCGAACTTTGTTCCTTAGGCTCCCT
CAATAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13785.49 Da        Isoelectric Point: 6.2066

>AT167444 WP_020218963.1 NZ_CP058780:662511-662879 [Shigella flexneri]
VSDSRHETNYPDDHNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp

>AT167444 NZ_CP075129:201866-202153 [Salmonella enterica subsp. enterica serovar Rubislaw]
ATGCTATACAAGGGGTGTCTCATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAATCGCAGCGGGCGCTCATTGA
TGCAGCTGCGGAAATCCTTCACAAGTCACGTACAGATTTCATTCTGGAAACGGCCTGCCAGGCTGCCGAGAAAGTGATCC
TTGACCGCCGTGTATTTAACTTTAACGATGAGCAATATGAGGAGTTCATCAATCTGCTTGATGCACCGGTCGCAGATGAT
CCCGTTATCGAAAAACTGCTGGCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4V2J0G6

Antitoxin

Source ID Structure
AlphaFold DB A0A7L7B777

References