Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | phd-doc/Doc-Phd |
| Location | 20970..21571 | Replicon | plasmid unnamed2 |
| Accession | NZ_CP058773 | ||
| Organism | Shigella flexneri strain STLIN_11 | ||
Toxin (Protein)
| Gene name | doc | Uniprot ID | - |
| Locus tag | HZS97_RS24415 | Protein ID | WP_284527120.1 |
| Coordinates | 20970..21350 (-) | Length | 127 a.a. |
Antitoxin (Protein)
| Gene name | phd | Uniprot ID | U9YQH9 |
| Locus tag | HZS97_RS24420 | Protein ID | WP_001190712.1 |
| Coordinates | 21350..21571 (-) | Length | 74 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HZS97_RS24390 (HZS97_24020) | 16412..17854 | - | 1443 | WP_001472843.1 | hypothetical protein | - |
| HZS97_RS24395 (HZS97_24025) | 17896..19088 | - | 1193 | Protein_16 | terminase | - |
| HZS97_RS24400 (HZS97_24030) | 19174..19626 | - | 453 | WP_001326849.1 | late promoter-activating protein | - |
| HZS97_RS24405 (HZS97_24035) | 19715..20758 | - | 1044 | WP_208557430.1 | DUF968 domain-containing protein | - |
| HZS97_RS24410 (HZS97_24040) | 20786..20965 | - | 180 | WP_284527118.1 | PdcA protein | - |
| HZS97_RS24415 (HZS97_24045) | 20970..21350 | - | 381 | WP_284527120.1 | type II toxin-antitoxin system death-on-curing family toxin | Toxin |
| HZS97_RS24420 (HZS97_24050) | 21350..21571 | - | 222 | WP_001190712.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| HZS97_RS24425 (HZS97_24055) | 21644..22033 | - | 390 | WP_168420616.1 | S24 family peptidase | - |
| HZS97_RS24430 (HZS97_24060) | 22207..22791 | + | 585 | WP_284527123.1 | DNA-binding protein | - |
| HZS97_RS24435 (HZS97_24065) | 22792..23148 | + | 357 | WP_284527125.1 | hypothetical protein | - |
| HZS97_RS24440 (HZS97_24070) | 24224..24586 | - | 363 | WP_284527127.1 | hypothetical protein | - |
| HZS97_RS24445 (HZS97_24075) | 24583..25593 | - | 1011 | WP_284527129.1 | hypothetical protein | - |
| HZS97_RS24450 (HZS97_24080) | 25590..26105 | - | 516 | WP_001229203.1 | hypothetical protein | - |
| HZS97_RS24455 (HZS97_24085) | 26107..26295 | - | 189 | WP_000797279.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..95902 | 95902 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 127 a.a. Molecular weight: 13634.32 Da Isoelectric Point: 5.1514
>T167441 WP_284527120.1 NZ_CP058773:c21350-20970 [Shigella flexneri]
MRHISPEELIALHDANISRYGGLPGMSDPGRAEAIIGRVQARVAYEEITDLFEVSATYLVATARGHIFNDANKRTALNSA
LLFLRRNGIQVYDSPELADLTVGAATGEISVSSVADTLRRLYGSSE
MRHISPEELIALHDANISRYGGLPGMSDPGRAEAIIGRVQARVAYEEITDLFEVSATYLVATARGHIFNDANKRTALNSA
LLFLRRNGIQVYDSPELADLTVGAATGEISVSSVADTLRRLYGSSE
Download Length: 381 bp
>T167441 NZ_CP075128:4670591-4671073 [Salmonella enterica subsp. diarizonae serovar 60:r:e,n,x,z15]
ATGGAAATAAATGTTACTGCACCTGAGCTGCTGAACGAGGAGCATATTCTCCAATCTTTCGATTGCGGGAATGATGTATT
AAGCGACTGGCTTTGCCGCCGCGCTATGAAGAATCAGCACCTCAATGCATCCCGTACATTTGTGATCTGCCTTGAATGCA
CAAAACGCGTAGTAGGATATTATTCTATTGCGACGGGATCTATAAGCCATGTCGATTTAGGTCGCAGCCTGCGTCAGAAT
ATGCCCGATCCTGTTCCAGTTGTTTTATTGGGACGTCTTGCTATTGATAAGTGTACTCAGGGTCAAAATTTCGGTAAATG
GCTGCTTAATGATGCTGTAACGCGAGTATCAAACCTGGCAGATCAGGTGGGGATTAAAGCGATCATGGTGCATGCTATTG
ATGAACAAGCGAAAGCATTCTATGAATATTTTGGCTTCGTTCAGTCCCCCGTTGCACCAAACACATTGTTCTACAAGATT
TAA
ATGGAAATAAATGTTACTGCACCTGAGCTGCTGAACGAGGAGCATATTCTCCAATCTTTCGATTGCGGGAATGATGTATT
AAGCGACTGGCTTTGCCGCCGCGCTATGAAGAATCAGCACCTCAATGCATCCCGTACATTTGTGATCTGCCTTGAATGCA
CAAAACGCGTAGTAGGATATTATTCTATTGCGACGGGATCTATAAGCCATGTCGATTTAGGTCGCAGCCTGCGTCAGAAT
ATGCCCGATCCTGTTCCAGTTGTTTTATTGGGACGTCTTGCTATTGATAAGTGTACTCAGGGTCAAAATTTCGGTAAATG
GCTGCTTAATGATGCTGTAACGCGAGTATCAAACCTGGCAGATCAGGTGGGGATTAAAGCGATCATGGTGCATGCTATTG
ATGAACAAGCGAAAGCATTCTATGAATATTTTGGCTTCGTTCAGTCCCCCGTTGCACCAAACACATTGTTCTACAAGATT
TAA
Antitoxin
Download Length: 74 a.a. Molecular weight: 8133.10 Da Isoelectric Point: 4.7708
>AT167441 WP_001190712.1 NZ_CP058773:c21571-21350 [Shigella flexneri]
MQSINFRTARGNLSEVLNNVEAGEEVEITRRGREPAVIVSKATFEAYKKAALDAEFASLFDTLDSTNKELVNR
MQSINFRTARGNLSEVLNNVEAGEEVEITRRGREPAVIVSKATFEAYKKAALDAEFASLFDTLDSTNKELVNR
Download Length: 222 bp
>AT167441 NZ_CP075128:4670316-4670600 [Salmonella enterica subsp. diarizonae serovar 60:r:e,n,x,z15]
ATGCAAACTACAACCCGTAAATCTATTCGTAATAAACAAATAAATATTCGAGCGACTGATGAGGAGCGCGCAGTAATTGA
CTATGCAGCAAAGTTGGTCAGTAAAAATCGCACTGATTTCATCATAGAGAAAGCTGTGAATGAAGCTCAGAATATCATTC
TGGATCAGCGAGTTTTCGTTCTGGATGATGCTCGTTACCAGGCATTCATTGAACAGCTCGAAGCCCCAGTTCAGAATGTT
GAGGGTCGTCAGCGGCTGATGGATGTAAAACCTGAATGGAAATAA
ATGCAAACTACAACCCGTAAATCTATTCGTAATAAACAAATAAATATTCGAGCGACTGATGAGGAGCGCGCAGTAATTGA
CTATGCAGCAAAGTTGGTCAGTAAAAATCGCACTGATTTCATCATAGAGAAAGCTGTGAATGAAGCTCAGAATATCATTC
TGGATCAGCGAGTTTTCGTTCTGGATGATGCTCGTTACCAGGCATTCATTGAACAGCTCGAAGCCCCAGTTCAGAATGTT
GAGGGTCGTCAGCGGCTGATGGATGTAAAACCTGAATGGAAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|