Detailed information of TA system TA167435

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/LOTUS_5_Limkain_b1(toxin)
• Location: 4651082..4651698
• Replicon: chromosome
• Accession: NZ_CP058771
• Organism: Shigella flexneri strain STLIN_11

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: HZS97_RS22570
• Protein ID: WP_284526834.1
• Coordinates: 4651082..4651456 (-)
• Length: 125 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: S1E7W9
• Locus tag: HZS97_RS22575
• Protein ID: WP_001086388.1
• Coordinates: 4651456..4651698 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (7-115)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 125 a.a.
• Molecular weight: 13946.17 Da
• Isoelectric Point: 7.0126

>T167435 WP_284526834.1 NZ_CP058771:c4651456-4651082 [Shigella flexneri]
MGKRTALFDTNILIDLFSGRIEAKQALEAWPLQNAISLVTWMEVLVGAKKYDQEHRTRIAMSAFNVIGISQDIAERSVAL
RQEYRMKLPDAIILATAQIYGFELVTRNTRDFAGIAGVVTPYEL

Nucleotide

• Length: 375 bp

>T167435 NZ_CP075128:831648-832061 [Salmonella enterica subsp. diarizonae serovar 60:r:e,n,x,z15]
GTGGTCCTGTGGCAATCTGAATTACGCGTCTCATGGCGCGCTCAGTGGATCTCGTTGCTTATTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCATTGTGGATGATGCTACTGTCGCTGGTCGTGTTTGACTGCG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAAATCAAGCTGCTAATGGATGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTTTTGCGTCCGCCCTGGTTACTGAGGAGCGGGATGGTGTTGCGTTTACGCGCTGAGTCTGGGCACCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGCAGCGGAATGGCGTGAGTTGCGTCGGATAATGTTACAGCAACCAATAT
CGCGCCAACACTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9244.40 Da
• Isoelectric Point: 4.2092

>AT167435 WP_001086388.1 NZ_CP058771:c4651698-4651456 [Shigella flexneri]
MNSLAGIDMGRILLDLSNEVIKQLDDLEVQRNLPRADLLREAVDQYLINQSQTARTSVPGIWQGCEEDGVEYQRKLREEW

Nucleotide

• Length: 243 bp

>AT167435 NZ_CP075128:831401-831667 [Salmonella enterica subsp. diarizonae serovar 60:r:e,n,x,z15]
ATGGACATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGCGACGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGATGACCCGGATT
TATTTAACTGGTTGATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Antitoxin

• PDB: 2K5J
• AlphaFold DB: A0A4P7TTH6