Detailed information of TA system TA167433

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 4222245..4222767
• Replicon: chromosome
• Accession: NZ_CP058771
• Organism: Shigella flexneri strain STLIN_11

Toxin (Protein)

• Gene name: relE
• Uniprot ID: V0SDB6
• Locus tag: HZS97_RS20540
• Protein ID: WP_001105432.1
• Coordinates: 4222245..4222535 (-)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: HZS97_RS20545
• Protein ID: WP_284526805.1
• Coordinates: 4222525..4222767 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HZS97_RS20525 (4217408)	4217408..4219063	+	1656	WP_001301172.1	alpha,alpha-phosphotrehalase	-
HZS97_RS20530 (4219457)	4219457..4221595	+	2139	WP_000187791.1	anaerobic ribonucleoside-triphosphate reductase	-
HZS97_RS20535 (4221780)	4221780..4222244	+	465	WP_001106226.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
HZS97_RS20540 (4222245)	4222245..4222535	-	291	WP_001105432.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HZS97_RS20545 (4222525)	4222525..4222767	-	243	WP_284526805.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
HZS97_RS20550 (4222959)	4222959..4223345	-	387	WP_001232255.1	cytochrome b562	-
HZS97_RS20555 (4223400)	4223400..4224752	-	1353	WP_001162171.1	metalloprotease PmbA	-
HZS97_RS20560 (4224847)	4224847..4225398	+	552	WP_000166270.1	ribosome biogenesis factor YjgA	-
HZS97_RS20565 (4225486)	4225486..4226859	-	1374	WP_001219792.1	UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-82)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (2-72)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11311.21 Da
• Isoelectric Point: 10.0238

>T167433 WP_001105432.1 NZ_CP058771:c4222535-4222245 [Shigella flexneri]
MNYELAFDPRALKEWQKLGVTVREQFKKKLEDVLKRPRNPSAKLRDLPDCYKIKLRTLGYRLVYSVNDKELLVLVIAIGK
RENSAVYEDATKRLDE

Nucleotide

• Length: 291 bp

>T167433 NZ_CP075128:641068-641343 [Salmonella enterica subsp. diarizonae serovar 60:r:e,n,x,z15]
ATGAAACAGGTATTAAAAGATTTTGACGTCGCAGACTATTTAGAGGACGAGGATGATGTTATCGCTTATCTAAATGCCGT
TATTGCCGAGGGTGACAATAAACAACTTTTCATTGCGCTGGGCAACATTGCAAGAGCAAGAAATATAAGCCGTATTTCAA
AAGAAACCGGAATCAGCAGGGAGGGAATTTATAAAGCACTTTCAGGCGATGGAAATCCATCATTTAACACCCTTTCTAAA
ATAACTAAAGCGATGGGGTTAGATCTTCACTTTTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9109.51 Da
• Isoelectric Point: 5.1369

>AT167433 WP_284526805.1 NZ_CP058771:c4222767-4222525 [Shigella flexneri]
MATLNVRPDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAENGRMPVKTLTVSDSEEALLRTVRERLANPQEAIKVRLDEL

Nucleotide

• Length: 243 bp

>AT167433 NZ_CP075128:640770-641066 [Salmonella enterica subsp. diarizonae serovar 60:r:e,n,x,z15]
ATGATTGACATAAAAACAACACCAGAGGCCGAGAAGTGGCTAAAGGGATTGAAAGACCGGGTAGCGAAATCAAAGATATT
AATCAGAATCGACAGAATGAGAACGGGGAACTTTGGTGATGTTGAGCCAGTAGGCGGCGGGTTATCTGAATTGCGTATAC
ATCACGGCAAAGGTTATCGGGTTTATTTTGGGAATAAAAACAACGAAATAATATTAATTCTTTGTGGCGGGGATAAAAGC
ACACAGCAGGATGATATACAGAAAGCGAAACAGATAGCCAAAAAATGGGGGTTTTAA

Structures

Toxin

• AlphaFold DB: V0SDB6