Detailed information of TA system TA167433

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 4222245..4222767
• Replicon: chromosome
• Accession: NZ_CP058771
• Organism: Shigella flexneri strain STLIN_11

Toxin (Protein)

• Gene name: relE
• Uniprot ID: V0SDB6
• Locus tag: HZS97_RS20540
• Protein ID: WP_001105432.1
• Coordinates: 4222245..4222535 (-)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: HZS97_RS20545
• Protein ID: WP_284526805.1
• Coordinates: 4222525..4222767 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-82)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (2-72)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11311.21 Da
• Isoelectric Point: 10.0238

>T167433 WP_001105432.1 NZ_CP058771:c4222535-4222245 [Shigella flexneri]
MNYELAFDPRALKEWQKLGVTVREQFKKKLEDVLKRPRNPSAKLRDLPDCYKIKLRTLGYRLVYSVNDKELLVLVIAIGK
RENSAVYEDATKRLDE

Nucleotide

• Length: 291 bp

>T167433 NZ_CP075128:641068-641343 [Salmonella enterica subsp. diarizonae serovar 60:r:e,n,x,z15]
ATGAAACAGGTATTAAAAGATTTTGACGTCGCAGACTATTTAGAGGACGAGGATGATGTTATCGCTTATCTAAATGCCGT
TATTGCCGAGGGTGACAATAAACAACTTTTCATTGCGCTGGGCAACATTGCAAGAGCAAGAAATATAAGCCGTATTTCAA
AAGAAACCGGAATCAGCAGGGAGGGAATTTATAAAGCACTTTCAGGCGATGGAAATCCATCATTTAACACCCTTTCTAAA
ATAACTAAAGCGATGGGGTTAGATCTTCACTTTTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9109.51 Da
• Isoelectric Point: 5.1369

>AT167433 WP_284526805.1 NZ_CP058771:c4222767-4222525 [Shigella flexneri]
MATLNVRPDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAENGRMPVKTLTVSDSEEALLRTVRERLANPQEAIKVRLDEL

Nucleotide

• Length: 243 bp

>AT167433 NZ_CP075128:640770-641066 [Salmonella enterica subsp. diarizonae serovar 60:r:e,n,x,z15]
ATGATTGACATAAAAACAACACCAGAGGCCGAGAAGTGGCTAAAGGGATTGAAAGACCGGGTAGCGAAATCAAAGATATT
AATCAGAATCGACAGAATGAGAACGGGGAACTTTGGTGATGTTGAGCCAGTAGGCGGCGGGTTATCTGAATTGCGTATAC
ATCACGGCAAAGGTTATCGGGTTTATTTTGGGAATAAAAACAACGAAATAATATTAATTCTTTGTGGCGGGGATAAAAGC
ACACAGCAGGATGATATACAGAAAGCGAAACAGATAGCCAAAAAATGGGGGTTTTAA

Structures

Toxin

• AlphaFold DB: V0SDB6