Detailed information of TA system TA167430

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): itaRT/DUF1778(antitoxin)
• Location: 3632163..3632999
• Replicon: chromosome
• Accession: NZ_CP058771
• Organism: Shigella flexneri strain STLIN_11

Toxin (Protein)

• Gene name: itaT
• Uniprot ID: -
• Locus tag: HZS97_RS17720
• Protein ID: WP_284526720.1
• Coordinates: 3632601..3632999 (+)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: itaR
• Uniprot ID: -
• Locus tag: HZS97_RS17715
• Protein ID: WP_284526719.1
• Coordinates: 3632163..3632474 (+)
• Length: 104 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HZS97_RS17690 (3627183)	3627183..3628130	+	948	WP_001239436.1	cytochrome o ubiquinol oxidase subunit II	-
HZS97_RS17695 (3628152)	3628152..3630143	+	1992	WP_000467180.1	cytochrome o ubiquinol oxidase subunit I	-
HZS97_RS17700 (3630133)	3630133..3630747	+	615	WP_000179819.1	cytochrome o ubiquinol oxidase subunit III	-
HZS97_RS17705 (3630747)	3630747..3631076	+	330	WP_000019869.1	cytochrome o ubiquinol oxidase subunit IV	-
HZS97_RS17710 (3631088)	3631088..3631978	+	891	WP_000971336.1	heme o synthase	-
HZS97_RS17715 (3632163)	3632163..3632474	+	312	WP_284526719.1	DUF1778 domain-containing protein	Antitoxin
HZS97_RS17720 (3632601)	3632601..3632999	+	399	WP_284526720.1	GNAT family N-acetyltransferase	Toxin
HZS97_RS17725 (3633055)	3633055..3633899	-	845	Protein_3472	tetratricopeptide repeat protein	-
HZS97_RS17730 (3634306)	3634306..3635670	+	1365	WP_001000963.1	MFS transporter	-
HZS97_RS17735 (3635798)	3635798..3636289	-	492	WP_001138904.1	nucleotide binding protein YajQ	-
HZS97_RS17740 (3636457)	3636457..3637368	+	912	WP_000705865.1	2-dehydropantoate 2-reductase	-
HZS97_RS17745 (3637331)	3637331..3637921	+	591	WP_001276296.1	protein deglycase YajL	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (20-108)

Antitoxin

• Vibrio phage ICP1, Orf50 (19-96)

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 14505.99 Da
• Isoelectric Point: 9.8684

>T167430 WP_284526720.1 NZ_CP058771:3632601-3632999 [Shigella flexneri]
VRNSDCAAKALIDRQSGELIGICTFTAYSLEKQRVSGVLQGSQPSEIGVVRLVMLGVARKYQKRGFGQDLLCNFFEHVKI
IHRALPIKGVYLDADPAAINFYTRLGFVQLSARPNVFGAVPMFLAIQHILAA

Nucleotide

• Length: 399 bp

>T167430 NZ_CP075127:c4558608-4558234 [Salmonella enterica]
ATGGTCAAAGGGTCTGCGCTTTTTGATACCAATATCCTCATCGACCTGTTTAGCGGTCGAATTGAAGCGAAACATGCGCT
GGAAGCGTATCCGCCACAAAATGCGATTAGCCTTATCACATGGATGGAAGTGATGGTGGGTGCTAAGAAATATCATCAGG
AAAACCGCACGCGCATTGCATTAAGTGCGTTCAATATTATTGGCGTAACACAGGAAATCGCGGAGCGAAGCGTCATTGTC
AGGCAGGAGTATGGCATGAAACTCCCGGATGCGATCATTCTGGCCACTGCACAAGTCCATCGTTGTGAGCTTGTGACGCG
TAATACAAAAGACTTTGCCGATATTCCGGGAGTGATCACGCCGTATCACTTGTAG

Antitoxin

Protein

• Length: 104 a.a.
• Molecular weight: 11410.12 Da
• Isoelectric Point: 10.4825

>AT167430 WP_284526719.1 NZ_CP058771:3632163-3632474 [Shigella flexneri]
MHGKTVALPDIDKTLKNARVELKTSPDAKNKLREAAQAVGVDLSAFILSAAMERAESVLDNQRRRELSNQSWELMNQLIA
EPAQPTLALKALMKRKNSDGRQA

Nucleotide

• Length: 312 bp

>AT167430 NZ_CP075127:c4558850-4558608 [Salmonella enterica]
ATGATGGCTGGGATGGATATGGGCAGAATTTTACTCGATTTATCAGACGATGTGATTAAACGGCTTGACGATCTCAAGGT
GCAACGCAACCTACCTCGTGCAGAACTCTTGCGGGAGGCCGTTGAGCAGTATCTGGAAAGACAGGATCGGGCTGAGACCA
CAATTTCGAAAGCATTGGGGCTCTGGCAAGGCTGTGAGGAAGATGGCGTTGAATACCAACGTAAACTTCGTGAGGAATGG
TAA