Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3598085..3598703 Replicon chromosome
Accession NZ_CP058771
Organism Shigella flexneri strain STLIN_11

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag HZS97_RS17550 Protein ID WP_001291435.1
Coordinates 3598485..3598703 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag HZS97_RS17545 Protein ID WP_000344800.1
Coordinates 3598085..3598459 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZS97_RS17535 (3593174) 3593174..3594367 + 1194 WP_240763433.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HZS97_RS17540 (3594390) 3594390..3597539 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
HZS97_RS17545 (3598085) 3598085..3598459 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
HZS97_RS17550 (3598485) 3598485..3598703 + 219 WP_001291435.1 HHA domain-containing protein Toxin
HZS97_RS17555 (3598875) 3598875..3599426 + 552 WP_000102564.1 maltose O-acetyltransferase -
HZS97_RS17560 (3599542) 3599542..3600012 + 471 WP_000136192.1 YlaC family protein -
HZS97_RS17565 (3600176) 3600176..3601726 + 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
HZS97_RS17570 (3601768) 3601768..3602121 - 354 WP_000878140.1 DUF1428 domain-containing protein -
HZS97_RS17580 (3602500) 3602500..3602811 + 312 WP_000409911.1 MGMT family protein -
HZS97_RS17585 (3602842) 3602842..3603414 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T167429 WP_001291435.1 NZ_CP058771:3598485-3598703 [Shigella flexneri]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T167429 NZ_CP075127:c4254272-4253781 [Salmonella enterica]
ATGATCTCCACCCCTGAGCCGCTTCATGCCGGACATATTCTTACTCCGTTTTGCTGCGGTGTGGATTCTATAGATAACTG
GCTGAAACAGCGGGCGATGAAAAATCAGACCACTGGCGCGTCCCGTACCTTTGTGTGTTGTGGCAGCGATTCGAACGTAC
TGGCCTATTACTCGCTGGCGTCCAGCGCGGTCACGACGAATACCTCCCCCGGTCGCTTTCGTCGCAATATGCCTGACCCG
ATTCCGGTTGTGGTATTGGGGCGTCTGGCGGTGGATAAATCGCTTCATGGGCAGGGCGTCGCTCGGGCGCTGGTACGCGA
CGCAGGGCTGCGGGTTATTCAGGTGGCGGAGACTATCGGCATTCGTGGGATGCTGGTTCACGCCCTGTCGGATGAAGCGC
GGGAATTTTATCAGCGGGTGGGGTTTGTACCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGGGGGATTTGGTG
GAGAGTGTTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT167429 WP_000344800.1 NZ_CP058771:3598085-3598459 [Shigella flexneri]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT167429 NZ_CP075127:c4254562-4254269 [Salmonella enterica]
ATGCCAGCCGCAAACAGTATGGCGATGAAACGTGAAACCCTGAACCTGCGTATCAAACCCGCCGAGCGCGATCTTATTGA
TCGAGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAAGCTGCCCGTGCTGCCGCAGAAGAAGCGCTTA
TCGAACAACGCATCATTATGGCCGATCCAGAGGCTTATCAGGAGTTTCTCGTTCGTTTGGATCAAACACCTTCACCTAAT
GCCGCACTGCGTAAAACCATGCAGACCCCTGCGCCGTGGGAGCAGGAAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References