Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 3173211..3173916 Replicon chromosome
Accession NZ_CP058771
Organism Shigella flexneri strain STLIN_11

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag HZS97_RS15405 Protein ID WP_284526659.1
Coordinates 3173211..3173597 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag HZS97_RS15410 Protein ID WP_001280945.1
Coordinates 3173587..3173916 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZS97_RS15385 (3169215) 3169215..3169841 + 627 WP_001295292.1 glutathione S-transferase GstB -
HZS97_RS15390 (3169838) 3169838..3170953 - 1116 WP_000555031.1 aldose sugar dehydrogenase YliI -
HZS97_RS15395 (3171064) 3171064..3171447 - 384 WP_000497137.1 biofilm formation regulator BssR -
HZS97_RS15400 (3171660) 3171660..3172985 + 1326 WP_000049367.1 30S ribosomal protein S12 methylthiotransferase RimO -
HZS97_RS15405 (3173211) 3173211..3173597 + 387 WP_284526659.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HZS97_RS15410 (3173587) 3173587..3173916 + 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
HZS97_RS15415 (3173986) 3173986..3175314 - 1329 WP_000086904.1 GGDEF domain-containing protein -
HZS97_RS15420 (3175322) 3175322..3177670 - 2349 WP_001334886.1 EAL domain-containing protein -
HZS97_RS15425 (3177848) 3177848..3178759 - 912 WP_001236051.1 glutathione ABC transporter permease GsiD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14222.33 Da        Isoelectric Point: 9.7308

>T167427 WP_284526659.1 NZ_CP058771:3173211-3173597 [Shigella flexneri]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSGSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

>T167427 NZ_CP075127:3658799-3659056 [Salmonella enterica]
ATGAATGCCTCCGGCGTCAGCGTCCGCCATATCAACAGCGAAACCTGCATGACCGCCTGTTACTCACAAATCCCCAGCCA
GCACCTTAAGGGTGACTGGCAGGAAGAAGCGGGATTTGAGACCGGGCGCAGCGTCACCGTGAAGATTTCACAGGAGTGTA
TTGTGCTGATGGCGGACAGTAACGAGGAACAGAAGCTGCGCGAACAGCTTTACAAGGCTGAACAGGTGGTTAAGGGGATG
CGGGACGTGATTGTTTAG

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT167427 WP_001280945.1 NZ_CP058771:3173587-3173916 [Shigella flexneri]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp

>AT167427 NZ_CP075127:c3658974-3658642 [Salmonella enterica]
TCCGCCATCAGCACAATACACTCCTGTGAAATCTTCACGGTGACGCTGCGCCCGGTCTCAAATCCCGCTTCTTCCTGCCA
GTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCAGCCGGCTGCC
GGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References