Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 211016..211628 Replicon chromosome
Accession NZ_CP058771
Organism Shigella flexneri strain STLIN_11

Toxin (Protein)


Gene name hicA Uniprot ID U9YXE2
Locus tag HZS97_RS01005 Protein ID WP_000833473.1
Coordinates 211016..211201 (+) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag HZS97_RS01010 Protein ID WP_284526887.1
Coordinates 211218..211628 (+) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZS97_RS00990 (206482) 206482..207777 + 1296 WP_284526886.1 Fic family protein -
HZS97_RS00995 (207885) 207885..209423 + 1539 WP_000183980.1 aldehyde dehydrogenase AldB -
HZS97_RS01000 (209464) 209464..210543 - 1080 WP_000061475.1 type I restriction enzyme HsdR N-terminal domain-containing protein -
HZS97_RS01005 (211016) 211016..211201 + 186 WP_000833473.1 type II toxin-antitoxin system HicA family toxin Toxin
HZS97_RS01010 (211218) 211218..211628 + 411 WP_284526887.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HZS97_RS01015 (211740) 211740..213718 - 1979 Protein_201 glycoside hydrolase family 127 protein -
HZS97_RS01020 (213729) 213729..215129 - 1401 Protein_202 MFS transporter -
HZS97_RS01025 (215355) 215355..216170 + 816 WP_284526888.1 AraC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6800.89 Da        Isoelectric Point: 11.7053

>T167411 WP_000833473.1 NZ_CP058771:211016-211201 [Shigella flexneri]
VKSADVIAILKQHGWEHIRTRGSHHQFRHPVHPGLVTVPHPKKDIKPGTLAQIGRQAGLTF

Download         Length: 186 bp

>T167411 NZ_CP075125:2102632-2102735 [Salmonella enterica]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 15243.12 Da        Isoelectric Point: 4.3751

>AT167411 WP_284526887.1 NZ_CP058771:211218-211628 [Shigella flexneri]
MFYPAYIHSDPDGSASGFFPDVPGCYFAGDTLDNAFEDARSALVAHFETLCEMDEELPLPGSVETHLVQRAQDFIGGQWL
LVDINMNQFEGRAERINITMPKRLLNKIDTYVRNNPDYANRSAFLAEAARRVLPGV

Download         Length: 411 bp

>AT167411 NZ_CP075125:c2102737-2102594 [Salmonella enterica]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9YXE2

Antitoxin

Source ID Structure

References