Detailed information of TA system TA167410

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 70672..71470
• Replicon: chromosome
• Accession: NZ_CP058771
• Organism: Shigella flexneri strain STLIN_11

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: U9XMP3
• Locus tag: HZS97_RS00310
• Protein ID: WP_000854735.1
• Coordinates: 70672..71049 (-)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: HZS97_RS00315
• Protein ID: WP_284526860.1
• Coordinates: 71096..71470 (-)
• Length: 125 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HZS97_RS00280 (66034)	66034..66957	-	924	WP_000535961.1	carboxylate/amino acid/amine transporter	-
HZS97_RS00285 (67068)	67068..68252	-	1185	WP_001172876.1	sugar efflux transporter	-
HZS97_RS00290 (68649)	68649..68810	-	162	Protein_57	RhuM family protein	-
HZS97_RS00295 (69048)	69048..69890	-	843	WP_284526859.1	DUF4942 domain-containing protein	-
HZS97_RS00300 (69975)	69975..70172	-	198	WP_000839265.1	DUF957 domain-containing protein	-
HZS97_RS00305 (70184)	70184..70675	-	492	WP_023155722.1	DUF5983 family protein	-
HZS97_RS00310 (70672)	70672..71049	-	378	WP_000854735.1	TA system toxin CbtA family protein	Toxin
HZS97_RS00315 (71096)	71096..71470	-	375	WP_284526860.1	type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA	Antitoxin
HZS97_RS00320 (71633)	71633..71854	-	222	WP_000692345.1	DUF987 domain-containing protein	-
HZS97_RS00325 (71923)	71923..72399	-	477	WP_284526861.1	RadC family protein	-
HZS97_RS00330 (72414)	72414..72893	-	480	WP_284526862.1	antirestriction protein	-
HZS97_RS00335 (73159)	73159..73977	-	819	WP_284526863.1	DUF932 domain-containing protein	-
HZS97_RS00340 (74068)	74068..74277	-	210	WP_023155727.1	DUF905 family protein	-
HZS97_RS00345 (74307)	74307..74984	-	678	WP_023155728.1	hypothetical protein	-
HZS97_RS00350 (75131)	75131..75811	-	681	Protein_69	WYL domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	57411..120262	62851

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14061.07 Da
• Isoelectric Point: 8.2904

>T167410 WP_000854735.1 NZ_CP058771:c71049-70672 [Shigella flexneri]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ

Nucleotide

• Length: 378 bp

>T167410 NZ_CP075125:c1313013-1312831 [Salmonella enterica]
ATGAAATATAACGAGTTCAGGCGGTGGCTCATCCAACAGGGTGCAAAGTTCATAAATGCACCGGATGGCGGCAGCCATCA
GCGTGTCATACTGAACGGGAAAGAATCTGTATTTCCCTGCCATGGCGCCAAAGAAATGCCGGAGCCGCTCAGAAAGAAAA
TACTCAAGGATTTGGGGCTTTAA

Antitoxin

Protein

• Length: 125 a.a.
• Molecular weight: 13687.47 Da
• Isoelectric Point: 6.6240

>AT167410 WP_284526860.1 NZ_CP058771:c71470-71096 [Shigella flexneri]
VSDTLSGTTHPDDNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYMAVYPTLAPATTS

Nucleotide

• Length: 375 bp

>AT167410 NZ_CP075125:c1312802-1312368 [Salmonella enterica]
ATGTTTAACTATGCTGTGAAACCTGAGTATGATCCCGCAACAGAAAGCTGGGTTGTCACATGCCGGGATCTGCCACTATT
TAACTCCGTGAGTTTCAGCATTGACGATGCGCTTCTTGAGGCGGTTGATGGTGCCATCGTTGCACTCTCAATCGAAATCG
ACGCACGCCGTCCAGTCCCCATCGCCAGCCAGCCCGAAGAAGGGGAGTATGTCATTCATCTTCCCGTTCTGGTTGTGATG
AAAGCCGCGCTGCATAATGCAATGATTTCCACAGGGACACGAAAATCCGATCTTGCCCGAACTATGGGGATGAAAGGTCC
CCAGATAGATCGCCTCCTGGATGTTTGCCACTCATCGAAAGTGGAAACAGTAGAACTCGCTCTTCAGCAACTCAACCGGA
CTGTACAGATAAGCGTTGATAACGTTGCGGTATAA

Structures

Toxin

• AlphaFold DB: U9XMP3