Detailed information of TA system TA167405

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/LOTUS_5_Limkain_b1(toxin)
• Location: 5040020..5040645
• Replicon: chromosome
• Accession: NZ_CP058758
• Organism: Klebsiella pneumoniae strain STLIN_3

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: HZT06_RS24715
• Protein ID: WP_021312635.1
• Coordinates: 5040020..5040403 (-)
• Length: 128 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: J2DFR0
• Locus tag: HZT06_RS24720
• Protein ID: WP_004150355.1
• Coordinates: 5040403..5040645 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HZT06_RS24700 (HZT06_24640)	5037386..5038288	+	903	WP_002882822.1	formate dehydrogenase subunit beta	-
HZT06_RS24705 (HZT06_24645)	5038285..5038920	+	636	WP_002882818.1	formate dehydrogenase cytochrome b556 subunit	-
HZT06_RS24710 (HZT06_24650)	5038917..5039846	+	930	WP_004150358.1	formate dehydrogenase accessory protein FdhE	-
HZT06_RS24715 (HZT06_24655)	5040020..5040403	-	384	WP_021312635.1	type II toxin-antitoxin system VapC family toxin	Toxin
HZT06_RS24720 (HZT06_24660)	5040403..5040645	-	243	WP_004150355.1	CopG family transcriptional regulator	Antitoxin
HZT06_RS24725 (HZT06_24665)	5040850..5041767	+	918	WP_080816047.1	alpha/beta hydrolase	-
HZT06_RS24730 (HZT06_24670)	5041781..5042722	-	942	WP_004178031.1	fatty acid biosynthesis protein FabY	-
HZT06_RS24735 (HZT06_24675)	5042767..5043204	-	438	WP_002882809.1	D-aminoacyl-tRNA deacylase	-
HZT06_RS24740 (HZT06_24680)	5043201..5044061	-	861	WP_002882807.1	virulence factor BrkB family protein	-
HZT06_RS24745 (HZT06_24685)	5044055..5044654	-	600	WP_004151865.1	glucose-1-phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (7-112)

Antitoxin

• Predicted DNA-binding protein, ribbon-helix-helix domain (16-47)

Sequences

Toxin

Protein

• Length: 128 a.a.
• Molecular weight: 14349.56 Da
• Isoelectric Point: 7.3178

>T167405 WP_021312635.1 NZ_CP058758:c5040403-5040020 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVATPYEIHPE

Nucleotide

• Length: 384 bp

>T167405 NZ_CP075122:4490149-4490460 [Salmonella enterica subsp. enterica serovar Enteritidis]
GTGCATGTTATCAGCCGAAAACCGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCTCTCACTGAGTTGCT
GAATGTTCTGGAGAAAAAAACACTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCACTGGATAATTTTAAGCACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATATGATCGGGGTAATAAAGAATGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9567.83 Da
• Isoelectric Point: 4.3509

>AT167405 WP_004150355.1 NZ_CP058758:c5040645-5040403 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Nucleotide

• Length: 243 bp

>AT167405 NZ_CP075122:4490457-4490903 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAAGCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACACCTGGAGAAAACGCCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTCAAACTACCAGCAGATGCCTTCATCGAGTAG

Structures

Antitoxin

• AlphaFold DB: A0A0H3GGU9