Detailed information of TA system TA167404

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 4715648..4717329
• Replicon: chromosome
• Accession: NZ_CP058758
• Organism: Klebsiella pneumoniae strain STLIN_3

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: -
• Locus tag: HZT06_RS23215
• Protein ID: WP_135725749.1
• Coordinates: 4715648..4716565 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A6TH05
• Locus tag: HZT06_RS23220
• Protein ID: WP_004177809.1
• Coordinates: 4716571..4717329 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HZT06_RS23195 (HZT06_23130)	4710954..4712474	+	1521	WP_002885173.1	sugar ABC transporter ATP-binding protein	-
HZT06_RS23200 (HZT06_23135)	4712471..4713469	+	999	WP_002885172.1	ribose ABC transporter permease	-
HZT06_RS23205 (HZT06_23140)	4713500..4714441	+	942	WP_002885156.1	ABC transporter substrate-binding protein	-
HZT06_RS23210 (HZT06_23145)	4714516..4715523	+	1008	WP_004177805.1	carbohydrate kinase family protein	-
HZT06_RS23215 (HZT06_23150)	4715648..4716565	-	918	WP_135725749.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
HZT06_RS23220 (HZT06_23155)	4716571..4717329	-	759	WP_004177809.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
HZT06_RS23225 (HZT06_23160)	4717415..4718143	-	729	WP_002885152.1	response regulator transcription factor	-
HZT06_RS23230 (HZT06_23165)	4718416..4720563	+	2148	WP_077598858.1	formate dehydrogenase subunit alpha	-
HZT06_RS23235 (HZT06_23170)	4721025..4721711	+	687	WP_004151733.1	tetratricopeptide repeat protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34759.22 Da
• Isoelectric Point: 5.2585

>T167404 WP_135725749.1 NZ_CP058758:c4716565-4715648 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSEMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

>T167404 NZ_CP075122:c4488916-4488605 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGAGGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28548.92 Da
• Isoelectric Point: 10.0870

>AT167404 WP_004177809.1 NZ_CP058758:c4717329-4716571 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

>AT167404 NZ_CP075122:c4488604-4488314 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAGCCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAAC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA

Structures

Antitoxin

• AlphaFold DB: A6TH05