Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3865904..3866523 Replicon chromosome
Accession NZ_CP058758
Organism Klebsiella pneumoniae strain STLIN_3

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag HZT06_RS19095 Protein ID WP_002892050.1
Coordinates 3866305..3866523 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag HZT06_RS19090 Protein ID WP_002892066.1
Coordinates 3865904..3866278 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZT06_RS19080 (HZT06_19040) 3861056..3862249 + 1194 WP_240730479.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HZT06_RS19085 (HZT06_19045) 3862272..3865418 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
HZT06_RS19090 (HZT06_19050) 3865904..3866278 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
HZT06_RS19095 (HZT06_19055) 3866305..3866523 + 219 WP_002892050.1 HHA domain-containing protein Toxin
HZT06_RS19100 (HZT06_19060) 3866682..3867248 + 567 WP_002892030.1 maltose O-acetyltransferase -
HZT06_RS19105 (HZT06_19065) 3867220..3867360 - 141 WP_004147370.1 hypothetical protein -
HZT06_RS19110 (HZT06_19070) 3867381..3867851 + 471 WP_002892026.1 YlaC family protein -
HZT06_RS19115 (HZT06_19075) 3867826..3869277 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
HZT06_RS19120 (HZT06_19080) 3869378..3870076 + 699 WP_002892021.1 GNAT family protein -
HZT06_RS19125 (HZT06_19085) 3870073..3870213 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
HZT06_RS19130 (HZT06_19090) 3870213..3870476 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T167401 WP_002892050.1 NZ_CP058758:3866305-3866523 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T167401 NZ_CP075122:c4031478-4031170 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCAATACATGGTTTATCGCAATAAAGGAAACAGCAAGGCTTATCCTTATTTACTTGATGTGCAAAGCGATATTATTGA
TGAACTGCATACTCGCATGGTTATCCCATTGTTTCCTGTGAGCAGATTGGTAAATAACCCAGTTAAGCGCCTCACGCCCA
CTCTGAATGTGGAAGGTAATGACTATCTGGTGATGACTCACGAAATGGCGAGTATCAGGCTTTCGCAGATTGGTGATGAG
GTGATGGACGTTCGTTCCCACAGGCAAACCATCAAAAATGCTCTCGATTTTATCTTTGACGGGTTCTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT167401 WP_002892066.1 NZ_CP058758:3865904-3866278 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT167401 NZ_CP075122:c4031720-4031481 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCCGGGTATGAGTGTACGACATAAAAAAACAGTCAGTGTCACGCTGGAACCTGCATTGCTTCAGCAAGCCCGTGATGC
AGGTATTAATCTGTCAGCGGTGCTTACCGCCGCGCTGAAAGAGGAAATCAGTGCCACAGGCGTTGAACGCTGGAAAGCAG
AAAATAGAGCGGGTTTGCAGGAGCTCAATCGTATTACTGATGAGCACGGCCTTTTATCGGACGATTACAGGACGTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References