Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2562097..2563685 Replicon chromosome
Accession NZ_CP058758
Organism Klebsiella pneumoniae strain STLIN_3

Toxin (Protein)


Gene name hipA Uniprot ID A0A2X3IYA0
Locus tag HZT06_RS12740 Protein ID WP_032103210.1
Coordinates 2562097..2563419 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag HZT06_RS12745 Protein ID WP_002904790.1
Coordinates 2563419..2563685 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZT06_RS12725 (HZT06_12695) 2557153..2559654 + 2502 WP_101999384.1 fimbria/pilus outer membrane usher protein -
HZT06_RS12730 (HZT06_12700) 2559642..2560646 + 1005 WP_101999385.1 fimbrial protein -
HZT06_RS12735 (HZT06_12705) 2560788..2562080 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
HZT06_RS12740 (HZT06_12710) 2562097..2563419 - 1323 WP_032103210.1 type II toxin-antitoxin system HipA family toxin Toxin
HZT06_RS12745 (HZT06_12715) 2563419..2563685 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
HZT06_RS12750 (HZT06_12720) 2563950..2564276 - 327 WP_101999386.1 hydroxyisourate hydrolase -
HZT06_RS12755 (HZT06_12725) 2564273..2564773 - 501 WP_101999387.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
HZT06_RS12760 (HZT06_12730) 2564751..2566130 - 1380 WP_101999388.1 nucleobase:cation symporter-2 family protein -
HZT06_RS12765 (HZT06_12735) 2566476..2567630 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
HZT06_RS12770 (HZT06_12740) 2567611..2568534 - 924 WP_008804925.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49097.38 Da        Isoelectric Point: 7.5357

>T167400 WP_032103210.1 NZ_CP058758:c2563419-2562097 [Klebsiella pneumoniae]
MATLTTWMNNVRVGSLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T167400 NZ_CP075122:c3981457-3981170 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCCGATGGAGTTTGAATGGGATGCGAACAAGGCTAAAAGCAACCTGAGGAAGCACGGTGTCCGCTTTGAGGATGCGGT
ACTGGTGTTTGACGATCCCCGACACCTGTCACGTCAGGAGCGTTATGAGAATGGAGAATATCGTTGGCAGACCCTCGGCC
TTGTTCATGGCATTGTGGTCATTCTGGTTGCTCATAGCGTTCGGTTCGAAAGTGGTTTTGAAGTTATCCGTATCATCAGC
GCTCGCAAGGCAGACAGAAAAGAGAGGAATCGTTATGAGCATGGTTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT167400 WP_002904790.1 NZ_CP058758:c2563685-2563419 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp

>AT167400 NZ_CP075122:c3981183-3980881 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGAGCATGGTTAAACATAAACGCGGCAATGCATCCGCGCTGAGTGCTCAGCATGAGGCTGAACTGAAGGCGCTGGCGAA
AAAATCAGATGATGAGATTGATTACAGCGACATTCCCGCTTCGGAGGATGGGCAGTGGTCTGAAGCAGTGCGTGGTAAGT
TTTTTCGCCCGTTAAAAACTCAGGCCTCGGTGCGTATTGACGCCGATGTGATGGAGTGGCTGAAACGGCCAGGAAAAGGC
TACCAGACGCGGCTCAATGCCATTCTGCGCGAGGCGATGCTGCGCGAGCAAAATAAGAAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2X3IYA0

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References